Evidence map›Paper›PMID 29495426›Full record

ArticleInternational journal of molecular sciences2018

Chronic Blockade of Brain Endothelin Receptor Type-A (ET

Luis R Cassinotti, María J Guil, Mercedes I Schöller, Mónica P Navarro, Liliana G Bianciotti, Marcelo S Vatta

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Luis R CassinottiCátedra de Fisiología, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, 1113 Buenos Aires, Argentina. lcassinotti@ffyb.uba.ar.
María J GuilCátedra de Fisiología, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, 1113 Buenos Aires, Argentina. jguil@ffyb.uba.ar.
Mercedes I SchöllerCátedra de Fisiología, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, 1113 Buenos Aires, Argentina. mscholler@ffyb.uba.ar.
Mónica P NavarroInstituto de Química y Metabolismo del Fármaco (IQUIMEFA), CONICET-Universidad de Buenos Aires, 1113 Buenos Aires, Argentina. mnavarro@ffyb.uba.ar.
Liliana G BianciottiCátedra de Fisiopatología, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, 1113 Buenos Aires, Argentina. lbianc@ffyb.uba.ar.
Marcelo S VattaCátedra de Fisiología, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, 1113 Buenos Aires, Argentina. mvatta@ffyb.uba.ar.ORCID 0000-0003-1456-4408
Consejo Nacional de Investigaciones Científicas y Técnicas · AR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Overactivity of the sympathetic nervous system and central endothelins (ETs) are involved in the development of hypertension. Besides the well-known brain structures involved in the regulation of blood pressure like the hypothalamus or locus coeruleus, evidence suggests that the olfactory bulb (OB) also modulates cardiovascular function. In the present study, we evaluated the interaction between the endothelinergic and catecholaminergic systems in the OB of deoxycorticosterone acetate (DOCA)-salt hypertensive rats. Following brain ET receptor type A (ET

Indexed as

AnimalsBlood PressureCatecholaminesDesoxycorticosterone AcetateDisease Models, AnimalEndothelin A Receptor AntagonistsEnzyme ActivationGene ExpressionHeart RateHypertensionMaleOlfactory BulbPhosphorylationRatsReceptor, Endothelin ATyrosine 3-MonooxygenaseCatecholaminesDesoxycorticosterone AcetateEndothelin A Receptor AntagonistsReceptor, Endothelin ATyrosine 3-MonooxygenaseBQ610endothelinhypertensionsystolic blood pressuretyrosine hydroxylase

Identifiers

PMID29495426
PMCPMC5877521
OpenAlexW2790663808

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.