Evidence map›Paper›PMID 29495404›Full record

ArticleInternational journal of molecular sciences2018

Targeting Glioblastoma Cells Expressing CD44 with Liposomes Encapsulating Doxorubicin and Displaying Chlorotoxin-IgG Fc Fusion Protein.

Hafizah Mahmud, Tomonari Kasai, Apriliana Cahya Khayrani, Mami Asakura, Aung Ko Ko Oo, Juan Du, Arun Vaidyanath, Samah El-Ghlban, Akifumi Mizutani, Akimasa Seno and 3 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 33 citations in OpenAlex.

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  11. Neuropilin-1 drives tumor-specific uptake of chlorotoxin.Cell communication and signaling : CCS · 2019
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 2 countries.

Hafizah MahmudDepartment of Medical Bioengineering, Graduate School of Natural Science and Technology, Okayama University, Okayama 700-0080, Japan. hfzhmhmd@gmail.com.
Tomonari KasaiDepartment of Medical Bioengineering, Graduate School of Natural Science and Technology, Okayama University, Okayama 700-0080, Japan. t-kasai@okayama-u.ac.jp.
Apriliana Cahya KhayraniDepartment of Medical Bioengineering, Graduate School of Natural Science and Technology, Okayama University, Okayama 700-0080, Japan. apriliana41@gmail.com.ORCID 0000-0001-9160-7446
Mami AsakuraDepartment of Medical Bioengineering, Graduate School of Natural Science and Technology, Okayama University, Okayama 700-0080, Japan. asakura@okayama-u.ac.jp.
Aung Ko Ko OoDepartment of Medical Bioengineering, Graduate School of Natural Science and Technology, Okayama University, Okayama 700-0080, Japan. kokooo.aung@gmail.com.
Juan DuDepartment of Medical Bioengineering, Graduate School of Natural Science and Technology, Okayama University, Okayama 700-0080, Japan. djmail@yeah.net.
Arun VaidyanathDepartment of Medical Bioengineering, Graduate School of Natural Science and Technology, Okayama University, Okayama 700-0080, Japan. arunvnath@okayama-u.ac.jp.
Samah El-GhlbanDepartment of Chemistry, Biochemistry Division, Faculty of Science, El Menoufia University, Shebin El Kom, Menoufia 32511, Egypt. S_elghlban@yahoo.com.
Akifumi MizutaniDepartment of Medical Bioengineering, Graduate School of Natural Science and Technology, Okayama University, Okayama 700-0080, Japan. mizut-a@cc.okayama-u.ac.jp.
Akimasa SenoDepartment of Medical Bioengineering, Graduate School of Natural Science and Technology, Okayama University, Okayama 700-0080, Japan. aseno@okayama-u.ac.jp.ORCID 0000-0002-9664-9490
Hiroshi MurakamiDepartment of Medical Bioengineering, Graduate School of Natural Science and Technology, Okayama University, Okayama 700-0080, Japan. muraka-h@cc.okayama-u.ac.jp.
Junko MasudaDepartment of Medical Bioengineering, Graduate School of Natural Science and Technology, Okayama University, Okayama 700-0080, Japan. junkomasuda@okayama-u.ac.jp.
Masaharu SenoDepartment of Medical Bioengineering, Graduate School of Natural Science and Technology, Okayama University, Okayama 700-0080, Japan. mseno@okayama-u.ac.jp.ORCID 0000-0001-8547-6259
Okayama University · JPMenoufia University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We recently have established a successful xenograft model of human glioblastoma cells by enriching hyaluronic acid-dependent spheroid-forming populations termed U251MG-P1 cells from U251MG cells. Since U251MG-P1 cells have been confirmed to express CD44 along with principal stemness marker genes,

Indexed as

Recombinant Fusion ProteinsAnimalsCell Line, TumorCell SurvivalDisease Models, AnimalDose-Response Relationship, DrugDoxorubicinFemaleGlioblastomaHumansHyaluronan ReceptorsImmunoglobulin Fc FragmentsImmunoglobulin GInhibitory Concentration 50Kruppel-Like Factor 4Matrix Metalloproteinase 2CD44 protein, humanChlorotoxinDoxorubicinHyaluronan ReceptorsImmunoglobulin Fc FragmentsImmunoglobulin GKLF4 protein, humanKlf4 protein, mouseKruppel-Like Factor 4liposomal doxorubicinMatrix Metalloproteinase 2Polyethylene GlycolsRecombinant Fusion ProteinsScorpion Venomsdoxorubicinglioblastoma cellsliposomeM-CTX-FcMMP-2specific targeting

Identifiers

PMID29495404
PMCPMC5877520
OpenAlexW2789262955

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.