ArticleNutrients2018
Lead Affects Vitamin D Metabolism in Rats.
Article in Nutrients, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Association between female circulating heavy metal concentration and abortion: a systematic review and meta-analysis.Frontiers in endocrinology · 2023Pooled it
- Serum 25-Hydroxyvitamin D Status Across Vertebrate Species: A Comparative Review.International journal of molecular sciences · 2026Review
- Lead poisoning in a 10-year-old boy with cyclic vomiting as the first symptom: a case report.Frontiers in pediatrics · 2025Article
- Metals on the Menu-Analyzing the Presence, Importance, and Consequences.Foods (Basel, Switzerland) · 2024Review
- Association between blood lead levels and parathyroid hormone among United States adolescents aged 12-19: a cross-sectional study.Frontiers in endocrinology · 2024Article
- Association of blood lead level with vitamin D binding protein, total and free 25-hydroxyvitamin D levels in middle-school children.The British journal of nutrition · 2022Article
- Protective effects of olive leaf extract against reproductive toxicity of the lead acetate in rats.Environmental science and pollution research international · 2021Article
- Protective Effect of Vitamin D3 Against Pb-Induced Neurotoxicity by Regulating the Nrf2 and NF-κB Pathways.Neurotoxicity research · 2021Article
- Vitamin D is associated with blood lead exposure through bone turnover in type 2 diabetes patients.Endocrine connections · 2021Article
- Novel Probable Glance at Inflammatory Scenario Development in Autistic Pathology.Frontiers in psychiatry · 2021Article
- Bioavailability of Different Vitamin D Oral Supplements in Laboratory Animal Model.Medicina (Kaunas, Lithuania) · 2019Article
- Role of Toxic Elements in Chronic Kidney Disease.Journal of health & pollution · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A negative association between blood lead and vitamin D concentrations has been reported, however, experimental data on the effect of lead (Pb) on vitamin D metabolism is scarce. We investigated the effects of Pb on serum vitamin D metabolites, vitamin D activating enzymes and vitamin D receptor (VDR) in rats. Newborn Wistar rat pups were exposed to 0.2% Pb-acetate via their dams' drinking water from post-natal day (PND) 1 to 21 and directly in drinking water until PND30. Serum 25-hydroxyvitamin D was analyzed with LC-MS/MS and 1,25-dihydroxyvitamin D with an immunoassay. Tissue expression of vitamin D activating enzymes and VDR were measured by Western blot and immunohistochemistry. Serum 25-hydroxyvitamin D was significantly decreased at both PND21 and PND30, whereas 1,25-dihydroxyvitamin D was decreased (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.