Evidence map›Paper›PMID 29494898›Full record

ArticleJournal of affective disorders2018

Changes in brain connectivity during a sham-controlled, transcranial magnetic stimulation trial for depression.

Stephan F Taylor, S Shaun Ho, Tessa Abagis, Mike Angstadt, Daniel F Maixner, Robert C Welsh, Luis Hernandez-Garcia

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of affective disorders, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 6 pooled it
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 6 syntheses or guidelines pooled it, 82 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Stephan F TaylorDepartment of Psychiatry, University of Michigan, Ann Arbor, MI, USA. Electronic address: sftaylor@umich.edu.
S Shaun HoDepartment of Psychiatry, Stony Brook University, USA.
Tessa AbagisDepartment of Psychology, University of Michigan, Ann Arbor, MI, USA.
Mike AngstadtDepartment of Psychiatry, University of Michigan, Ann Arbor, MI, USA.
Daniel F MaixnerDepartment of Psychiatry, University of Michigan, Ann Arbor, MI, USA.
Robert C WelshDepartment of Psychiatry, University of Utah, USA.
Luis Hernandez-GarciafMRI Laboratory, University of Michigan, Ann Arbor, MI, USA.
University of Michigan–Ann Arbor · USStony Brook University · USUniversity of Utah · US

Funding

Michigan Institute for Clinical and Health Research (MICHR)UL1TR002240 · NCATS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LUMENG, JULIE C, MASHOUR, GEORGE ALEXANDER · 2017 to 2022
$54.9M
Michigan Institute for Clinical and Health Research (MCHR)UL1TR000433 · NCATS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MASHOUR, GEORGE ALEXANDER · 2012 to 2016
$49.9M
Imaging Biomarkers for TMS treatment of DepressionR21MH098174 · NIMH · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI TAYLOR, STEPHAN F · 2013 to 2014
$428k
NCATS NIH HHS UL1 TR000433NCATS NIH HHS UL1 TR002240NIMH NIH HHS R21 MH098174
6 · The paper itself

Abstract

backgroundThe subgenual anterior cingulate cortex (sgACC) has been implicated in major depressive disorder (MDD), and this study evaluated sgACC connectivity before and after repetitive transcranial magnetic stimulation (rTMS) treatment.

methodsThirty-two MDD patients entered a sham-controlled, double-blinded, randomized trial of rTMS to the left dorsolateral prefrontal cortex (dlFPC). Subjects underwent resting state functional magnetic resonance imaging before and after 20 sessions of high frequency rTMS. Seed voxels identified the affective network (AN; sgACC, amygdala), default mode network (DMN; posterior cingulate cortex [PCC]), and fronto-parietal network (FPN; dlPFC stimulation site).

resultsThere was no significant effect of active rTMS over sham on the primary outcome measure (Montgomery-Asberg Depression Scale rating), with both groups improving over time, and no specific effect of rTMS (sham vs active) on connectivity. However, among patients who showed significant improvement, sgACC connectivity decreased for sham (to AN, trend to DMN) and active rTMS responders (to AN, DMN, FPN), but not in non-responders, who tended to maintain connectivity. Including subjects who started with sham but then received open-label active treatment, baseline connectivity from the PCC to the anterior insula was greater in non-responders compared to responders (n = 27, excluding 5 sham responders). LIMITATIONS: The sample size was small; the stimulation target was non-standard, and the lack of a significant clinical effect of rTMS limits conclusions about negative findings.

conclusionssgACC connectivity reduces along with depressive symptoms, not specific to rTMS therapy. Altered connectivity of DMN with anterior insula may reflect a type of patient less likely to respond to an intervention.

Indexed as

AdultBrainFemaleGyrus CinguliHumansMagnetic Resonance ImagingMajor Depressive DisorderMaleMiddle AgedNerve NetPrefrontal CortexTranscranial Magnetic StimulationAnterior insulaDefault mode networkDorsolateral prefrontal cortexFunctional magnetic resonance imagingPlaceboSubgenual cingulate gyrus

Identifiers

PMID29494898
PMCPMC5858982
OpenAlexW2793409980

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.