Evidence map›Paper›PMID 29494535›Full record

ArticleMolecules (Basel, Switzerland)2018

Trimethylamine-N-Oxide (TMAO)-Induced Impairment of Cardiomyocyte Function and the Protective Role of Urolithin B-Glucuronide.

Monia Savi, Leonardo Bocchi, Letizia Bresciani, Angela Falco, Federico Quaini, Pedro Mena, Furio Brighenti, Alan Crozier, Donatella Stilli, Daniele Del Rio

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
64citing papers in PubMed, 1 pooled it
7.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

64 citing papers in PubMed, 1 synthesis or guideline pooled it, 105 citations in OpenAlex.

  1. Pooled it
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  9. Gut Microbiota-Derived Metabolites Orchestrate Metabolic Reprogramming in Diabetic Cardiomyopathy: Mechanisms and Therapeutic Frontiers.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
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  11. Gut-heart axis: cardiac remodeling and heart failure in the context of inflammatory bowel disease and dysbiosis.American journal of physiology. Gastrointestinal and liver physiology · 2025
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  19. Role of Trimethylamine N-Oxide in Heart Failure.Reviews in cardiovascular medicine · 2024
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4 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Monia SaviDepartment of Chemistry, Life Sciences and Environmental Sustainability, University of Parma, Parco Area delle Scienze 11/A, 43124 Parma, Italy. monia.savi@unipr.it.ORCID 0000-0002-7895-7756
Leonardo BocchiDepartment of Chemistry, Life Sciences and Environmental Sustainability, University of Parma, Parco Area delle Scienze 11/A, 43124 Parma, Italy.ORCID 0000-0003-4799-2804
Letizia BrescianiDepartment of Veterinary Science, University of Parma, Strada del Taglio 10, 43126 Parma, Italy. letizia.bresciani@unipr.it.
Angela FalcoDepartment of Medicine and Surgery, University of Parma, Via A. Gramsci 14, 43126 Parma, Italy. angela.falco@unipr.it.
Federico QuainiDepartment of Medicine and Surgery, University of Parma, Via A. Gramsci 14, 43126 Parma, Italy. federico.quaini@unipr.it.
Pedro MenaDepartment of Food and Drugs, University of Parma, Parco Area delle Scienze 27/A, 43124 Parma, Italy. pedromiguel.menaparreno@unipr.it.ORCID 0000-0003-2150-2977
Furio BrighentiDepartment of Food and Drugs, University of Parma, Parco Area delle Scienze 27/A, 43124 Parma, Italy. furio.brighenti@unipr.it.
Alan CrozierDepartment of Nutrition, University of California, 3143 Meyer Hall One Shields Avenue, Davis, CA 95616-5270, USA. alan.crozier44@gmail.com.
Donatella StilliDepartment of Chemistry, Life Sciences and Environmental Sustainability, University of Parma, Parco Area delle Scienze 11/A, 43124 Parma, Italy. donatella.stilli@unipr.it.
Daniele Del RioDepartment of Veterinary Science, University of Parma, Strada del Taglio 10, 43126 Parma, Italy. daniele.delrio@unipr.it.ORCID 0000-0001-5394-1259
University of Parma · ITUniversity of California, Davis · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

One of the most recently proposed candidates as a potential trigger for cardiovascular diseases is trimethylamine-

Indexed as

AnimalsCalciumCalcium SignalingCardiotonic AgentsCoumarinsGlucuronidesGlycogenMaleMethylaminesMitochondria, HeartMyocytes, CardiacRats3,8-dihydroxy-6H-dibenzo(b,d)pyran-6-one glucuronideCalciumCardiotonic AgentsCoumarinsGlucuronidesGlycogenMethylaminestrimethyloxaminecardiomyocyte mechanicscardiovascular diseasesellagitanninsTrimethylamine-N-oxideurolithins

Identifiers

PMID29494535
PMCPMC6017162
OpenAlexW2792696458

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.