Evidence map›Paper›PMID 29494515›Full record

ArticleInternational journal of environmental research and public health2018

Comparison of Airway Responses Induced in a Mouse Model by the Gas and Particulate Fractions of Gasoline Direct Injection Engine Exhaust.

Caitlin L Maikawa, Naomi Zimmerman, Manuel Ramos, Mittal Shah, James S Wallace, Krystal J Godri Pollitt

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of environmental research and public health, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 10 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 3 countries.

Caitlin L MaikawaEnvironmental Health Sciences, University of Massachusetts, 686 North Pleasant Street, Goessmann Laboratory Room 175, Amherst, MA 01003, USA. cmaikawa@stanford.edu.
Naomi ZimmermanMechanical Engineering, University of British Columbia, Vancouver, BC V6T 1Z4, Canada. nzimmerman@mech.ubc.ca.
Manuel RamosMechanical and Industrial Engineering, University of Toronto, Toronto, ON M5S 3G8, Canada. manuel.ramos@mail.utoronto.ca.
Mittal ShahInstitute of Orthopaedics and Musculoskeletal Sciences, University College London, Royal National Orthopaedic Hospital, Stanmore HA7 4LP, UK. mittal.shah@ucl.ac.uk.ORCID 0000-0001-9771-4920
James S WallaceMechanical and Industrial Engineering, University of Toronto, Toronto, ON M5S 3G8, Canada. wallace@mie.utoronto.ca.
Krystal J Godri PollittEnvironmental Health Sciences, University of Massachusetts, 686 North Pleasant Street, Goessmann Laboratory Room 175, Amherst, MA 01003, USA. kpollitt@umass.edu.
University of Massachusetts Amherst · USUniversity of Toronto · CARoyal National Orthopaedic Hospital · GBUniversity of British Columbia · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diesel exhaust has been associated with asthma, but its response to other engine emissions is not clear. The increasing prevalence of vehicles with gasoline direct injection (GDI) engines motivated this study, and the objective was to evaluate pulmonary responses induced by acute exposure to GDI engine exhaust in an allergic asthma murine model. Mice were sensitized with an allergen to induce airway hyperresponsiveness or treated with saline (non-allergic group). Animals were challenged for 2-h to exhaust from a laboratory GDI engine operated at conditions equivalent to a highway cruise. Exhaust was filtered to assess responses induced by the particulate and gas fractions. Short-term exposure to particulate matter from GDI engine exhaust induced upregulation of genes related to polycyclic aromatic hydrocarbon (PAH) metabolism (

Indexed as

Air PollutantsAnimalsAntigens, DermatophagoidesAsthmaCytochrome P-450 CYP1B1FemaleGasolineMice, Inbred BALB CParticulate MatterPolycyclic Aromatic HydrocarbonsTumor Necrosis Factor-alphaVehicle EmissionsAir PollutantsAntigens, DermatophagoidesCyp1b1 protein, mouseCytochrome P-450 CYP1B1GasolineParticulate MatterPolycyclic Aromatic HydrocarbonsTumor Necrosis Factor-alphaVehicle EmissionsCyp1b1gasoline direct injection engine exhaustinflammationin vivopolycyclic aromatic hydrocarbonsTNFα

Identifiers

PMID29494515
PMCPMC5876974
OpenAlexW2789548204

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.