ReviewNutrients2018
Iodine as Essential Nutrient during the First 1000 Days of Life.
Review in Nutrients, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 87 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
87 citing papers in PubMed, 2 syntheses or guidelines pooled it, 182 citations in OpenAlex.
- Prevalence of insufficient iodine intake in pregnancy worldwide: a systematic review and meta-analysis.European journal of clinical nutrition · 2022Pooled it
- Iodine supplementation for the prevention of mortality and adverse neurodevelopmental outcomes in preterm infants.The Cochrane database of systematic reviews · 2019Pooled it
- Mild to Moderate Iodine Deficiency and Inadequate Iodine Intake in Lactating Women in the Inland Area of Norway.Nutrients · 2020Trial
- What Endocrinologists Should Know About Iodine: Population Deficiency, Individual Excess and Misinformation in the United Kingdom.Clinical endocrinology · 2026Review
- Article
- Nutraceutical Interventions in Stunting: Advances, Challenges, and Prospects.Food science & nutrition · 2026Review
- Evolving Concepts in Gestational Iodine Requirements.Healthcare (Basel, Switzerland) · 2026Review
- Empirical comparison of iodine excretion estimated from spot urine samples with measured 24-hour urinary iodine excretion in healthy adults.Journal of the Chinese Medical Association : JCMA · 2026Article
- The Impact of the COVID-19 Pandemic on Iodine Nutrition Status of Pregnant Women and Infants/Toddlers: Repeated Cross-Sectional Studies in Zhengzhou, China.Biological trace element research · 2026Article
- Iodine Supplementation Before, During and After Pregnancy.Geburtshilfe und Frauenheilkunde · 2026Article
- Micronutrient balance and brain function: neuropsychological, metabolic, and clinical interactions.Frontiers in molecular biosciences · 2026Review
- Feeding pattern and associated factors among children aged 6-23 months in the Tahtay Maichew district, northern Ethiopia.PLOS global public health · 2026Article
- Natural biostimulant formulations enriched with honey, iodine, and silymarin enhance drought tolerance and yield in faba bean (Vicia Faba L.) through antioxidant and hormonal regulation.BMC plant biology · 2025Article
- Eating within planetary boundaries - a cross-country analysis of iodine provision from the EAT-Lancet diet.NPJ science of food · 2025Article
- Key Messages of the Iodine Deficiency Working Group (AKJ): Maternal Hypothyroxinemia Due to Iodine Deficiency and Endocrine Disruptors as Risks for Child Neurocognitive Development.Geburtshilfe und Frauenheilkunde · 2025Article
- Effect of Iodine Nutrition During Pregnancy and Lactation on Child Cognitive Outcomes: A Review.Nutrients · 2025Review
- ORIGINS: Nutritional Profile of Children Aged One Year in a Longitudinal Birth Cohort.Nutrients · 2025Article
- Understanding Stunting: Impact, Causes, and Strategy to Accelerate Stunting Reduction-A Narrative Review.Nutrients · 2025Review
- Intake of iodine in a sample of UK mother-infant pairs, 6-12 months after birth: a cross-sectional study.Public health nutrition · 2025Article
- Beyond thyroid dysfunction: the systemic impact of iodine excess.Frontiers in endocrinology · 2025Review
27 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Iodine is an essential micronutrient incorporated into thyroid hormones. Although iodine deficiency can lead to a broad spectrum of disorders throughout life, it is most critical in the early stages of development, as the foetal brain is extremely dependent on iodine supply. During the last two decades, our understanding of thyroid physiology during gestation has substantially improved. Furthermore, thyroid hormone receptors have been identified and characterised in placental and embryonic tissues, allowing us to elucidate the maternal-foetal transfer of thyroid hormones. Experimental studies have demonstrated that the cyto-architecture of the cerebral cortex can be irreversibly disturbed in iodine deficiency causing abnormal neuron migratory patterns which are associated with cognitive impairment in children. In this context, the role of iodine as key factor in the programming of foetal and infant neurodevelopment, needs to be revisited with a special focus on areas of mild to moderate iodine deficiency. The objective of this review is to summarize the available evidence from both animals and human studies, for the effect of iodine deficiency (particularly, of maternal hypothyroxinemia) on brain development and neurological or behavioural disorders, such as lower intelligence quotient (IQ) or attention deficit hyperactivity disorder (ADHD).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.