Evidence map›Paper›PMID 29494506›Full record

ArticleInternational journal of molecular sciences2018

Anti-Hypertensive Effects of Acacia Polyphenol in Spontaneously Hypertensive Rats.

Nobutomo Ikarashi, Takahiro Toda, Yusuke Hatakeyama, Yoshiki Kusunoki, Risako Kon, Nanaho Mizukami, Miho Kaneko, Sosuke Ogawa, Kiyoshi Sugiyama

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.0field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 26 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Bioactive Phenolics and Polyphenols: Current Advances and Future Trends.International journal of molecular sciences · 2020
    Article
  10. Article
  11. Review
  12. Article
  13. Analysis of Flavonoid Metabolites in Citrus Peels (Molecules (Basel, Switzerland) · 2019
    Article
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Nobutomo IkarashiDepartment of Clinical Pharmacokinetics, Hoshi University, 2-4-41 Ebara, Shinagawa-ku, Tokyo 142-8501, Japan. ikarashi@hoshi.ac.jp.
Takahiro TodaDepartment of Clinical Pharmacokinetics, Hoshi University, 2-4-41 Ebara, Shinagawa-ku, Tokyo 142-8501, Japan. t.toda@thu.ac.jp.
Yusuke HatakeyamaDepartment of Clinical Pharmacokinetics, Hoshi University, 2-4-41 Ebara, Shinagawa-ku, Tokyo 142-8501, Japan. xdxexexnxfxoxvxwxaxnxdxsx@gmail.com.
Yoshiki KusunokiDepartment of Clinical Pharmacokinetics, Hoshi University, 2-4-41 Ebara, Shinagawa-ku, Tokyo 142-8501, Japan. p16kusunoki@hoshi.ac.jp.
Risako KonDepartment of Clinical Pharmacokinetics, Hoshi University, 2-4-41 Ebara, Shinagawa-ku, Tokyo 142-8501, Japan. r-kon@hoshi.ac.jp.
Nanaho MizukamiDepartment of Clinical Pharmacokinetics, Hoshi University, 2-4-41 Ebara, Shinagawa-ku, Tokyo 142-8501, Japan. m1616@hoshi.ac.jp.
Miho KanekoDepartment of Clinical Pharmacokinetics, Hoshi University, 2-4-41 Ebara, Shinagawa-ku, Tokyo 142-8501, Japan. m1703@hoshi.ac.jp.
Sosuke OgawaDepartment of Clinical Pharmacokinetics, Hoshi University, 2-4-41 Ebara, Shinagawa-ku, Tokyo 142-8501, Japan. ogawa@mimozax.co.jp.
Kiyoshi SugiyamaDepartment of Clinical Pharmacokinetics, Hoshi University, 2-4-41 Ebara, Shinagawa-ku, Tokyo 142-8501, Japan. sugiyama@hoshi.ac.jp.
Hoshi University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We have previously demonstrated that acacia polyphenol (AP) exerts strong anti-obesity, anti-diabetic, and anti-atopic dermatitis effects. In the present study, we investigated the anti-hypertensive effects of AP. Spontaneously hypertensive rats (SHR) with hypertension and control Wistar Kyoto rats (WKY) were used. WKY and SHR were fed AP-containing food or AP-free food (control group) ad libitum for 4 weeks, and their blood pressures were measured. After AP administration, both systolic and diastolic blood pressures were significantly lower in the SHR group than in the control group. There were no differences in the systolic or diastolic blood pressure of WKY between the AP group and the control group. Angiotensin-converting enzyme (ACE) activity,

Indexed as

AcaciaAnimalsAntihypertensive AgentsBlood PressureBody WeightDisease Models, AnimalEnzyme ActivationGene Expression RegulationHeart RateHypertensionKidneyMaleNADPH OxidasesOxidative StressPeptidyl-Dipeptidase APlant ExtractsAntihypertensive AgentsNADPH OxidasesPeptidyl-Dipeptidase APlant ExtractsPolyphenolsSuperoxide Dismutaseacacia polyphenolhypertensionnicotinamide adenine dinucleotide phosphate oxidasesuperoxide dismutase

Identifiers

PMID29494506
PMCPMC5877561
OpenAlexW2792665552

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.