ReviewAnesthesiology2018
Neuroimaging of Pain: Human Evidence and Clinical Relevance of Central Nervous System Processes and Modulation.
Review in Anesthesiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 116 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
116 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Functional MRI evidence of brain alterations in premenstrual dysphoric disorder: a systematic review.Frontiers in psychiatry · 2026Pooled it
- Pooled it
- Disentangling the Effects of Spinal Cord Injury and Related Neuropathic Pain on Supraspinal Neuroplasticity: A Systematic Review on Neuroimaging.Frontiers in neurology · 2019Pooled it
- Evidence for decreased Neurologic Pain Signature activation following thoracic spinal manipulation in healthy volunteers and participants with neck pain.NeuroImage. Clinical · 2019Trial
- Emerging preclinical evidence supports a potential role for cannabidiol in the management of sickle cell disease.Haematologica · 2026Review
- Longitudinal stability of data-driven fibromyalgia phenotypes across repeated clinical assessments.Pain reports · 2026Article
- The cortical morphology of cingulate cortex and microarchitecture of cingulum bundle correlate with cancer pain and anxiety in lung cancer patients.Brain imaging and behavior · 2026Article
- Non-Invasive Brain Stimulation for Core Symptoms of Chronic Primary Pain: A Meta-Analysis of RCTs.Brain sciences · 2026Review
- Concordance of cortical morphological anomalies with genetic predisposition to multisite chronic pain in females.The Korean journal of pain · 2026Article
- Psychiatric comorbidity patterns across disability-based fibromyalgia phenotypes.CNS spectrums · 2026Article
- Chronic Pain and Cognitive Dysfunction: Clinical Implement, Mechanism, and Therapeutic Strategy.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Review
- Chronic Pain and Opioids in the Elderly: Treating the Brain, Not Just the Body.International journal of environmental research and public health · 2026Review
- Beta-lactam Antibiotic Cefepime Attenuates Lipopolysaccharide-induced Pain and Depression By Modulating Inflammatory Response and Astroglial Glutamate Transporter in Mice.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2026Article
- The Predominant Role of Musical Valence Over Arousal in Pain Modulation: A Psychophysiological Study.International journal of psychology : Journal international de psychologie · 2026Article
- Neuroimaging-Guided Insights into the Molecular and Network Mechanisms of Chronic Pain and Neuromodulation.International journal of molecular sciences · 2026Review
- Abnormal Brain Structure and Function in People with Shoulder Pain: A Systematic Review of Neuroimaging Studies.Journal of pain research · 2026Review
- Atogepant modulates brain connectivity in episodic migraine: a longitudinal exploratory fMRI study.Frontiers in neurology · 2026Article
- The Role of Central Sensitization in Responsiveness to Brain Stimulation for Patients with Nonspecific Chronic Low Back Pain - An Exploratory Study.Journal of pain research · 2026Article
- Synaptic Dysfunction in the Anterior Cingulate Cortex Underlies Pain-Anxiety Comorbidity in a Mandibular Asymmetry Mouse Model.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- The pain of PTSD: integrating persistent or chronic pain within emotional processing theory of posttraumatic stress disorder.European journal of psychotraumatology · 2025Article
56 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Neuroimaging research has demonstrated definitive involvement of the central nervous system in the development, maintenance, and experience of chronic pain. Structural and functional neuroimaging has helped elucidate central nervous system contributors to chronic pain in humans. Neuroimaging of pain has provided a tool for increasing our understanding of how pharmacologic and psychologic therapies improve chronic pain. To date, findings from neuroimaging pain research have benefitted clinical practice by providing clinicians with an educational framework to discuss the biopsychosocial nature of pain with patients. Future advances in neuroimaging-based therapeutics (e.g., transcranial magnetic stimulation, real-time functional magnetic resonance imaging neurofeedback) may provide additional benefits for clinical practice. In the future, with standardization and validation, brain imaging could provide objective biomarkers of chronic pain, and guide treatment for personalized pain management. Similarly, brain-based biomarkers may provide an additional predictor of perioperative prognoses.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.