ArticleChemistry (Weinheim an der Bergstrasse, Germany)2018
Anthracene Bisureas as Powerful and Accessible Anion Carriers.
Article in Chemistry (Weinheim an der Bergstrasse, Germany), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 48 citations in OpenAlex.
- Anion Transport by Bambusuril-Bile Acid Conjugates: Drastic Effect of the Cholesterol Content.Angewandte Chemie (International ed. in English) · 2025Article
- The Role of the Organic Moiety in the Diffusion and Transport of Carboxylates into Liposomes.Molecules (Basel, Switzerland) · 2024Article
- Platinum-based metal complexes as chloride transporters that trigger apoptosis.Chemical science · 2024Article
- Multistate Redox-Switchable Ion Transport Using Chalcogen-Bonding Anionophores.Journal of the American Chemical Society · 2023Article
- Boosting Anion Transport Activity of Diamidocarbazoles by Electron Withdrawing Substituents.Frontiers in chemistry · 2021Article
- Anion carriers as potential treatments for cystic fibrosis: transport in cystic fibrosis cells, and additivity to channel-targeting drugs.Chemical science · 2019Article
- Heavy Pnictogenium Cations as Transmembrane Anion Transporters in Vesicles and Erythrocytes.Chem · 2019Article
- Influence of the Insertion Method of Aryl-Extended Calix[4]pyrroles into Liposomal Membranes on Their Properties as Anion Carriers.Chemistry (Weinheim an der Bergstrasse, Germany) · 2019Article
- Anthracene Bisureas as Powerful and Accessible Anion Carriers.Chemistry (Weinheim an der Bergstrasse, Germany) · 2018Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
Synthetic anion carriers (anionophores) have potential as biomedical research tools and as treatments for conditions arising from defective natural transport systems (notably cystic fibrosis). Highly active anionophores that are readily accessible and easily deliverable are especially valuable. Previous work has resulted in steroid and trans-decalin based anionophores with exceptional activity for chloride/nitrate exchange in vesicles, but poor accessibility and deliverability. This work shows that anthracene 1,8-bisureas can fulfil all three criteria. In particular, a bis-nitrophenyl derivative is prepared in two steps from commercial starting materials, yet shows comparable transport activity to the best currently known. Moreover, unlike earlier highly active systems, it does not need to be preincorporated in test vesicles but can be introduced subsequent to vesicle formation. This transporter also shows the ability to transfer between vesicles, and is therefore uniquely effective for anion transport at low transporter loadings. The results suggest that anthracene bisureas are promising candidates for application in biological research and medicine.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.