Evidence map›Paper›PMID 29493809›Full record

ArticleBritish journal of clinical pharmacology2018

Use of attention-deficit/hyperactivity disorder medication among older adults in Denmark.

Stina Schultz Ormhøj, Anton Pottegård, Christiane Gasse, Lotte Rasmussen

Abstract read
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Article in British journal of clinical pharmacology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Stina Schultz OrmhøjClinical Pharmacology and Pharmacy, Department of Public Health, University of Southern Denmark, DK-5000, Odense C, Denmark.
Anton PottegårdClinical Pharmacology and Pharmacy, Department of Public Health, University of Southern Denmark, DK-5000, Odense C, Denmark.ORCID 0000-0001-9314-5679
Christiane GasseNational Centre for Register-based Research, Aarhus University, Aarhus, Denmark.
Lotte RasmussenClinical Pharmacology and Pharmacy, Department of Public Health, University of Southern Denmark, DK-5000, Odense C, Denmark.ORCID 0000-0001-5962-6647

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsKnowledge on the use of attention-deficit/hyperactivity disorder (ADHD) medication among older adults is limited. We hypothesized that ADHD medication is used off-label in adults aged ≥50 years as part of palliative care in e.g. cancer patients. The aim of this study was to describe the use of ADHD medication among adults aged ≥50 years in Denmark.

methodsUsing the Danish health registries, we identified new users ≥50 years of ADHD medication during 2000-2012. We estimated the annual incidence of ADHD medication use and ADHD diagnoses. We described new users of ADHD medication according to co-medication, comorbidities and assessed the 1-year cumulative mortality rate. A posthoc analysis allowed us to include new users until 2015.

resultsWe identified 6690 new users of ADHD medication from 2000 to 2012. From 2000 to 2015 we observed an increase in the incidence of ADHD medication use from 12.5 to 30.3 per 100 000 person-years. However, the incidence rate decreased from 2010 to 2015. Throughout the study period, the incidence rate of ADHD diagnoses was low (overall prevalence among new users ≤2%). Opioids were the most frequent comedication used (used by 54%), while cancer was the most frequent diagnosis preceding treatment (prevalence of 52%). The 1-year cumulative mortality was 50%, primarily driven by patients with a preceding cancer diagnosis.

conclusionThere was an increase in the incidence of ADHD medication use in adults aged ≥50 years from 2000-2010 and a decreasing incidence from 2010-2015. Our results suggest that ADHD medication is used off-label in older adults as part of palliative care.

Indexed as

Central Nervous System StimulantsAgedAged, 80 and overAnalgesics, OpioidAttention Deficit Disorder with HyperactivityComorbidityDenmarkDrug PrescriptionsDrug Utilization ReviewFemaleHumansIncidenceMaleMiddle AgedNeoplasmsOff-Label UseAnalgesics, OpioidCentral Nervous System Stimulantsagedattention deficit disorder with hyperactivitydrug utilizationmethylphenidateoff-label use

Identifiers

PMID29493809
PMCPMC6005604

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.