Evidence map›Paper›PMID 29493507›Full record

ArticleeLife2018

A new role for a tumor-suppressing protein.

Jeremy S Setton, Simon N Powell

Abstract readComment
In one paragraph

Article in eLife, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Jeremy S SettonDepartment of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, United States.ORCID 0000-0002-0263-2306
Simon N PowellDepartment of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, United States.ORCID 0000-0002-8183-4765

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
MSK Paul Calabresi Career Development Award for Clinical OncologyK12CA184746 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI Omar Abdel-Wahab, Simon N. Powell · 2015 to 2026
$8.3M
The Response to a Site-Specific Blocked DNA Replication Fork in Human CancersR01CA187069 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI POWELL, SIMON N. · 2014 to 2018
$1.8M
Connections and redundancy in the BRCA1-BRCA2 pathway of homologous recombinationR01CA169306 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI POWELL, SIMON N. · 2013 to 2017
$1.8M
NCI NIH HHS K12 CA184746NCI NIH HHS P30 CA008748NCI NIH HHS R01 CA169306NCI NIH HHS R01 CA187069
6 · The paper itself

Abstract

In addition to its role in preventing tumors, the protein p53 appears to participate in a DNA repair process known as the replication-stress response.

Indexed as

NeoplasmsTumor Suppressor Protein p53DNA ReplicationGenomic InstabilityHomeostasisHumansMutagensRad52 DNA Repair and Recombination ProteinMutagensRad52 DNA Repair and Recombination ProteinRAD52 protein, humanTumor Suppressor Protein p53cancerchromosomesDNA replicationgenesgenome instabilityhumanmousep53replication forkreplication stress response

Identifiers

PMID29493507
PMCPMC5832416

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.