Evidence map›Paper›PMID 29493257›Full record

ReviewAmerican journal of physiology. Lung cellular and molecular physiology2018

Seeing cilia: imaging modalities for ciliary motion and clinical connections.

Jacelyn E Peabody, Ren-Jay Shei, Brent M Bermingham, Scott E Phillips, Brett Turner, Steven M Rowe, George M Solomon

Open access · bronzeAbstract readReview
In one paragraph

Review in American journal of physiology. Lung cellular and molecular physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 32 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Optical Imaging of Cilia in the Head and Neck.Journal of clinical medicine · 2025
    Review
  5. Metachrony drives effective mucociliary transport via a calcium-dependent mechanism.American journal of physiology. Lung cellular and molecular physiology · 2024
    Article
  6. Article
  7. Airway ciliated cells in adult lung homeostasis and COPD.European respiratory review : an official journal of the European Respiratory Society · 2023
    Review
  8. Mucociliary clearance augmenting drugs block SARS-CoV-2 replication in human airway epithelial cells.American journal of physiology. Lung cellular and molecular physiology · 2023
    Article
  9. Article
  10. Light-sheet laser speckle imaging for cilia motility assessment.Computational and structural biotechnology journal · 2023
    Article
  11. Review
  12. Article
  13. Article
  14. CFTR targeted therapies: recent advances in cystic fibrosis and possibilities in other diseases of the airways.European respiratory review : an official journal of the European Respiratory Society · 2020
    Review
  15. Article
  16. Article
  17. Review
  18. Functional Anatomic Imaging of the Airway Surface.Annals of the American Thoracic Society · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Jacelyn E PeabodyDepartment of Medicine, University of Alabama at Birmingham, Alabama.
Ren-Jay SheiDepartment of Medicine, University of Alabama at Birmingham, Alabama.ORCID 0000-0002-7733-643X
Brent M BerminghamDepartment of Medicine, University of Alabama at Birmingham, Alabama.
Scott E PhillipsDepartment of Medicine, University of Alabama at Birmingham, Alabama.
Brett TurnerDepartments of Pediatrics and Cell Developmental and Integrative Biology, University of Alabama at Birmingham, Alabama.
Steven M RoweDepartment of Medicine, University of Alabama at Birmingham, Alabama.
George M SolomonDepartment of Medicine, University of Alabama at Birmingham, Alabama.ORCID 0000-0003-3490-8474
University of Alabama at Birmingham · US

Funding

UAB CF Research and Translation Core CenterP30DK072482 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI George Martin Solomon · 2007 to 2026
$23.0M
Translational Program in CFTR-Related Airway DiseasesR35HL135816 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI ROWE, STEVEN MARK · 2017 to 2022
$6.3M
Training Program in Lung Biology and Translational MedicineT32HL105346 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI GAGGAR, AMIT · 2010 to 2025
$5.0M
UAB Center for Clinical and Translational Science (CCTS)KL2TR001419 · NCATS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI SAAG, KENNETH G · 2015 to 2018
$2.5M
NCATS NIH HHS KL2 TR001419NHLBI NIH HHS R35 HL135816NHLBI NIH HHS T32 HL105346NIDDK NIH HHS P30 DK072482
6 · The paper itself

Abstract

The respiratory tract is lined with multiciliated epithelial cells that function to move mucus and trapped particles via the mucociliary transport apparatus. Genetic and acquired ciliopathies result in diminished mucociliary clearance, contributing to disease pathogenesis. Recent innovations in imaging technology have advanced our understanding of ciliary motion in health and disease states. Application of imaging modalities including transmission electron microscopy, high-speed video microscopy, and micron-optical coherence tomography could improve diagnostics and be applied for precision medicine. In this review, we provide an overview of ciliary motion, imaging modalities, and ciliopathic diseases of the respiratory system including primary ciliary dyskinesia, cystic fibrosis, chronic obstructive pulmonary disease, and idiopathic pulmonary fibrosis.

Indexed as

CiliaCystic FibrosisKartagener SyndromePulmonary Disease, Chronic ObstructiveAnimalsHumansMucociliary Clearancecilia imagingciliary motionciliopathymucociliary transportprimary ciliary dyskinesia

Identifiers

PMID29493257
PMCPMC6032069
OpenAlexW2790038170

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.