ArticleCPT: pharmacometrics & systems pharmacology2018
Modeling Composite Assessment Data Using Item Response Theory.
Article in CPT: pharmacometrics & systems pharmacology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
36 citing papers in PubMed.
- Early exposure-response modeling of an interferon-beta monoclonal antibody (dazukibart) in adults with dermatomyositis.Journal of pharmacokinetics and pharmacodynamics · 2026Trial
- Exposure-response modeling of liver fat imaging endpoints in non-alcoholic fatty liver disease populations administered ervogastat alone and co-administered with clesacostat.CPT: pharmacometrics & systems pharmacology · 2025Trial
- Item response theory in early phase clinical trials: Utilization of a reference model to analyze the Montgomery-Åsberg Depression Rating Scale.CPT: pharmacometrics & systems pharmacology · 2023Trial
- Quantifying the Pharmacodynamics of Morphine in the Treatment of Postoperative Pain in Preverbal Children.Journal of clinical pharmacology · 2022Trial
- Improved Decision-Making Confidence Using Item-Based Pharmacometric Model: Illustration with a Phase II Placebo-Controlled Trial.The AAPS journal · 2021Trial
- Detecting placebo and drug effects on Parkinson's disease symptoms by longitudinal item-score models.CPT: pharmacometrics & systems pharmacology · 2021Trial
- An Innovative Pharmacometric Approach for the Simultaneous Analysis of Frequency, Duration and Severity of Migraine Events.Pharmaceutical research · 2020Trial
- Application of Item Response Theory to Model Disease Progression and Agomelatine Effect in Patients with Major Depressive Disorder.The AAPS journal · 2019Trial
- An item response theory based integrated model of headache, nausea, photophobia, and phonophobia in migraine patients.Journal of pharmacokinetics and pharmacodynamics · 2018Trial
- A Pharmacometric Analysis of Patient-Reported Outcomes in Breast Cancer Patients Through Item Response Theory.Pharmaceutical research · 2018Trial
- Real-world creatine supplementation: a large-scale cross-sectional study of use, knowledge, and experiences.Journal of the International Society of Sports Nutrition · 2026Article
- Tutorial on Analyzing Patient-Reported Outcome Measures in Clinical Development.Clinical and translational science · 2026Review
- Longitudinal Evaluation of an Abbreviated Patient-Reported Movement Disorder Society-sponsored revision of the Unified Parkinson's Disease Rating Scale (MDS-UPDRS) for Predicting Dopaminergic Therapy Initiation in Early Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2026Article
- Integrated Modeling of Digital-Motor and Clinician-Reported Outcomes Using Item Response Theory: Towards Powerful Trials for Rare Neurological Diseases.CPT: pharmacometrics & systems pharmacology · 2025Observational
- Reflection on clinical and methodological issues in rare disease clinical trials.Orphanet journal of rare diseases · 2025Article
- A tutorial on pharmacometric Markov models.CPT: pharmacometrics & systems pharmacology · 2025Article
- A Model-Based Evaluation of Noninvasive Biomarkers to Reflect Histological Nonalcoholic Fatty Liver Disease Scores.Pharmaceutical research · 2025Observational
- Efficiency of multivariate tests in trials in progressive supranuclear palsy.Scientific reports · 2024Article
- Sparse item testing of clinical scales in neurology trials to alleviate burden to patients.Journal of neurology · 2024Article
- Item performance of the scale for the assessment and rating of ataxia in rare and ultra-rare genetic ataxias.CPT: pharmacometrics & systems pharmacology · 2024Article
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Composite assessments aim to combine different aspects of a disease in a single score and are utilized in a variety of therapeutic areas. The data arising from these evaluations are inherently discrete with distinct statistical properties. This tutorial presents the framework of the item response theory (IRT) for the analysis of this data type in a pharmacometric context. The article considers both conceptual (terms and assumptions) and practical questions (modeling software, data requirements, and model building).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.