ArticleCNS neuroscience & therapeutics2018
Aberrant intrinsic functional connectivity in thalamo-cortical networks in major depressive disorder.
Article in CNS neuroscience & therapeutics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 53 citations in OpenAlex.
- Thalamocortical functional connectivity and rapid antidepressant and antisuicidal effects of low-dose ketamine infusion among patients with treatment-resistant depression.Molecular psychiatry · 2025Trial
- Brain structural-functional connectivity coupling and glucose metabolism in adolescents with bipolar disorder and major depressive disorder.European journal of nuclear medicine and molecular imaging · 2026Article
- Universum Inspired Graph Contrast Learning for Major Depressive Disorder Identification: In Functional Brain Network View.CNS neuroscience & therapeutics · 2026Article
- Individualized Subcortical Functional Brain Organization Is Related to Diagnosis, Symptoms, and Behavior in Major Depressive Disorder.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2026Article
- Associations Between Thalamic Gray Matter Volume and Psychomotor Symptoms in Major Depressive Disorder: A Voxel-Based Morphometry Study.Neuropsychiatric disease and treatment · 2026Article
- The delta/alpha ratio in sleep EEG increases with the severity of depression in patients over 50 years old.BMC psychiatry · 2025Article
- Altered static and dynamic functional network connectivity in individuals with subthreshold depression: a large-scale resting-state fMRI study.European archives of psychiatry and clinical neuroscience · 2025Article
- Thalamo-cortical neural mechanism of sodium salicylate-induced hyperacusis and anxiety-like behaviors.Communications biology · 2024Article
- Resting-state brain activity as a biomarker of chronic pain impairment and a mediator of its association with pain resilience.Human brain mapping · 2024Article
- Brain white matter changes and their associations with non-motor dysfunction in orthostatic hypotension in α-synucleinopathy: A NODDI study.CNS neuroscience & therapeutics · 2024Article
- A distinctive subcortical functional connectivity pattern linking negative affect and treatment outcome in major depressive disorder.Translational psychiatry · 2024Article
- Aberrant dynamic functional connectivity of thalamocortical circuitry in major depressive disorder.Journal of Zhejiang University. Science. B · 2024Article
- Neurobiological Underpinnings of Hyperarousal in Depression: A Comprehensive Review.Brain sciences · 2024Review
- Thalamo-cortical circuits associated with trait- and state-repetitive negative thinking in major depressive disorder.Journal of psychiatric research · 2023Article
- Abnormal dynamic functional connectivity of thalamic subregions in patients with first-episode, drug-naïve major depressive disorder.Frontiers in psychiatry · 2023Article
- Aberrant degree centrality of functional brain networks in subclinical depression and major depressive disorder.Frontiers in psychiatry · 2023Article
- Altered spatio-temporal state patterns for functional dynamics estimation in first-episode drug-naive major depression.Brain imaging and behavior · 2022Article
- Resting-State Functional Connectivity Impairment in Patients with Major Depressive Episode.International journal of environmental research and public health · 2022Article
- Alterations of functional connectivity of the lateral habenula in subclinical depression and major depressive disorder.BMC psychiatry · 2022Article
- 7T ultra-high-field neuroimaging for mental health: an emerging tool for precision psychiatry?Translational psychiatry · 2022Review
Corrections and comments
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Authors and funding
12 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveGrowing evidence has implicated dysfunction of the thalamus and its projection cortical targets in depression. However, the anatomical specificity of thalamo-cortical connectivity in major depressive disorder (MDD) remains unknown due to the regional heterogeneity of the thalamus and limited methods to examine this.
methodsResting-state fMRI was collected on 70 MDD patients and 70 healthy controls. The thalamus was parcellated based on connectivity with six predefined cortical regions of interest (ROIs). The segmented thalamic nuclei were used as seeds to map connectivity with the rest of the whole brain. The cortical-to-thalamus connectivity values and thalamus-based connectivity maps were compared between groups.
resultsThe cortical ROIs demonstrated correlations with spatially distinct zones within the thalamus. We found a trend toward reduced parietal ROI-to-thalamus connectivity in MDD. Importantly, MDD patients demonstrated reduced connectivity between prefrontal and parietal thalamus ROIs and bilateral middle frontal gyrus (MFG) and the right posterior default mode network (DMN) and between the prefrontal and motor thalamus ROIs and lateral temporal regions. Conversely, increased connectivity emerged between the motor thalamus ROI and right MFG and right medial frontal gyrus/anterior cingulate; between motor/somatosensory thalamus ROIs and right posterior DMN; between prefrontal/somatosensory thalamus ROIs and cerebellum; and between the parietal thalamus ROI and left insula.
conclusionsThis study is the first to examine the anatomical specificity of thalamo-cortical connectivity disturbances in MDD. Subjects with MDD demonstrated altered thalamo-cortical connectivity characterized by a complex pattern of region-dependent hypo- or hyperconnectivity. We therefore speculate that selectively modulating the connectivity of thalamo-cortical circuitry may be a potential novel therapeutic mechanism for MDD.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.