Evidence map›Paper›PMID 29493093›Full record

ArticleHIV medicine2018

Highlights of the 2017 European AIDS Clinical Society (EACS) Guidelines for the treatment of adult HIV-positive persons version 9.0.

L Ryom, C Boesecke, M Bracchi, J Ambrosioni, A Pozniak, J Arribas, G Behrens, Pgm Mallon, M Puoti, A Rauch and 6 more

Open access · hybridAbstract read
In one paragraph

Article in HIV medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 1 pooled it
17.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 1 synthesis or guideline pooled it, 137 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Analysis of HIV Drug Resistance Mutations Along With Treatment Outcomes of Efavirenz-Based Regimens in Patients With V179D/E Mutations in Guangzhou, China.The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2026
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  5. Article
  6. Article
  7. Review
  8. Article
  9. Roadmap for Achieving Universal Antiretroviral Treatment.Annual review of pharmacology and toxicology · 2023
    Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. NASH in HIV.Current HIV/AIDS reports · 2020
    Review
  16. Review
  17. Article
  18. Epidemiological trends in HCV transmission and prevalence in the Viennese HIV+ population.Liver international : official journal of the International Association for the Study of the Liver · 2020
    Article
  19. HIV and cardiovascular disease.The lancet. HIV · 2020
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 11 institutions in 7 countries.

L RyomCHIP, Department of Infectious Diseases, Section 2100, Finsencentret, Rigshospitalet, University Hospital of Copenhagen, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0002-6436-6461
C BoeseckeDepartment of Medicine, University of Bonn, Bonn, Germany.
M BracchiHIV/GUM Department, Chelsea and Westminster NHS Foundation Trust, London, UK.
J AmbrosioniInfectious Diseases Service, Hospital Clinic-IDIBAPS, University of Barcelona, Barcelona, Spain.
A PozniakChelsea and Westminister Hospital NHS Foundation Trust, London, UK.
J ArribasHIV Unit, Hospital La Paz, Madrid, Spain.
G BehrensClinic for Immunology and Rheumatology, Medical School Hannover, Hannover, Germany.
Pgm MallonHIV Molecular Research Group, School of Medicine, University College Dublin, Dublin, Ireland.
M PuotiDepartment of Infectious Diseases, Hospital Niguerda Ca' Granda, Milan, Italy.
A RauchDepartment of Infectious Diseases, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
J M MiroInfectious Diseases Service, Hospital Clinic-IDIBAPS, University of Barcelona, Barcelona, Spain.
O KirkCHIP, Department of Infectious Diseases, Section 2100, Finsencentret, Rigshospitalet, University Hospital of Copenhagen, University of Copenhagen, Copenhagen, Denmark.
C MarzoliniDivision of Infectious Diseases and Hospital Epidemiology, University Hospital Basel and University of Basel, Basel, Switzerland.
J D LundgrenCHIP, Department of Infectious Diseases, Section 2100, Finsencentret, Rigshospitalet, University Hospital of Copenhagen, University of Copenhagen, Copenhagen, Denmark.
M BattegayDivision of Infectious Diseases and Hospital Epidemiology, University Hospital Basel and University of Basel, Basel, Switzerland.
EACS Governing Board
University of Copenhagen · DKChelsea and Westminster Hospital NHS Foundation Trust · GBConsorci Institut D'Investigacions Biomediques August Pi I Sunyer · ESAzienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda · ITHospital Universitario La Paz · ESMedizinische Hochschule Hannover · DEUniversity College Dublin · IEUniversity of Basel · CHUniversity of Bern · CHUniversity of Bonn · DEUniversity of Liverpool · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe European AIDS Clinical Society (EACS) Guidelines have since 2005 provided multidisciplinary recommendations for the care of HIV-positive persons in geographically diverse areas. GUIDELINE HIGHLIGHTS: Major revisions have been made in all sections of the 2017 Guidelines: antiretroviral treatment (ART), comorbidities, coinfections and opportunistic diseases. Newly added are also a summary of the main changes made, and direct video links to the EACS online course on HIV Management. Recommendations on the clinical situations in which tenofovir alafenamide may be considered over tenofovir disoproxil fumarate are provided, and recommendations on which antiretrovirals can be used safely during pregnancy have been revised. Renal and bone toxicity and hepatitis C virus (HCV) treatment have been added as potential reasons for ART switches in fully virologically suppressed individuals, and dolutegravir/rilpivirine has been included as a treatment option. In contrast, dolutegravir monotherapy is not recommended. New recommendations on non-alcoholic fatty liver disease, chronic lung disease, solid organ transplantation, and prescribing in elderly are included, and human papilloma virus (HPV) vaccination recommendations have been expanded. All drug-drug interaction tables have been updated and new tables are included. Treatment options for direct-acting antivirals (DAAs) have been updated and include the latest combinations of sofosbuvir/velpatasvir/voxilaprevir and glecaprevir/pibrentasvir. Recommendations on management of DAA failure and acute HCV infection have been expanded. For treatment of tuberculosis (TB), it is underlined that intermittent treatment is contraindicated, and for resistant TB new data suggest that using a three-drug combination may be as effective as a five-drug regimen, and may reduce treatment duration from 18-24 to 6-10 months.

conclusionsVersion 9.0 of the EACS Guidelines provides a holistic approach to HIV care and is translated into the six most commonly spoken languages.

Indexed as

AdultAIDS-Related Opportunistic InfectionsAnti-Retroviral AgentsAntiretroviral Therapy, Highly ActiveCoinfectionDrug InteractionsEuropeFemaleHIV InfectionsHumansMalePractice Guidelines as TopicPregnancyPregnancy Complications, InfectiousSocieties, ScientificAnti-Retroviral Agentsantiretroviral treatmentARTcoinfectionscomorbiditiesEuropean AIDS Clinical Society guidelinesHBVHCVHIVopportunistic diseases

Identifiers

PMID29493093
PMCPMC5947127
OpenAlexW2791745392

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.