ArticleHuman brain mapping2018
Reduced olfactory bulb volume in depression-A structural moderator analysis.
Article in Human brain mapping, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.
- A systematic narrative review of the form, process, and function of sensory hyposensitivity in depression.Translational psychiatry · 2026Pooled it
- Altered gray matter volume in major depressive disorder patients with psychomotor retardation.Neuroreport · 2026Article
- Disrupted small-world white matter networks in patients with major depression and recent suicide plans or attempts.Brain imaging and behavior · 2024Article
- Y-chromosome in the olfactory neuroepithelium as a potential biomarker of depression in women with male offspring: an exploratory study.Molecular and cellular biochemistry · 2024Article
- Metformin Improves Comorbid Depressive Symptoms in Mice with Allergic Rhinitis by Reducing Olfactory Bulb Damage.Neurochemical research · 2023Article
- Article
- Olfactory brain activations in patients with Major Depressive Disorder.Scientific reports · 2023Article
- Olfactory Dysfunction in Mental Illness.Current allergy and asthma reports · 2023Review
- Association between chemosensory impairment with neuropsychiatric morbidity in post-acute COVID-19 syndrome: results from a multidisciplinary cohort study.European archives of psychiatry and clinical neuroscience · 2023Article
- Article
- Application of Intranasal Administration in the Delivery of Antidepressant Active Ingredients.Pharmaceutics · 2022Review
- Olfactory impairment in psychiatric disorders: Does nasal inflammation impact disease psychophysiology?Translational psychiatry · 2022Review
- Infiltration of peripheral immune cells into the olfactory bulb in a mouse model of acute nasal inflammation.Journal of neuroimmunology · 2022Article
- Olfactory Radioanatomical Findings in Patients With Cardiac Arrhythmias, COVID-19, and Healthy Controls.Cureus · 2022Article
- Interoceptive accuracy and its impact on neuronal responses to olfactory stimulation in the insular cortex.Human brain mapping · 2020Article
- Mechanisms Linking Olfactory Impairment and Risk of Mortality.Frontiers in neuroscience · 2020Review
- Reduced Olfactory Bulb Volume in Obesity and Its Relation to Metabolic Health Status.Frontiers in human neuroscience · 2020Article
- Article
- Neural plasticity in developing and adult olfactory pathways - focus on the human olfactory bulb.Journal of bioenergetics and biomembranes · 2019Review
- Olfactory bulbus volume and olfactory sulcus depth in psychotic patients and patients with anxiety disorder/depression.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2018Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRemoval of the olfactory bulb (OB) leads to depression like behavior in rodents. A link between depression and olfactory function is also established in humans. We hypothesized that the human OB volume relates to depressive state and tested whether such a potential coherence is moderated by structural alterations in other brain regions.
methodsEighty-three participants (32 patients with major depression and 51 matched healthy controls) underwent structural MR scanning. Individual OB volumes were compared between patients and controls and the impact of depression and comorbidity was analyzed with multiple regression analysis. Whole-brain voxel-based morphometry revealed structures co-varying with both depressive state and OB volume.
resultsThe OB volume of patients was significantly reduced and this reduction averaged out at 17% compared to the controls. The OB volume was correlated to the volume of the insula, superior temporal cortex, and amygdala. The independent variables of depression (β = -.37), age (β = -.25), and gender (β = -.40) explained the individual OB volume variation (R
conclusionsThe OB volume relates to depression in humans and to the volume of structures which are critical for salience detection. We assume that a reduced OB volume causes diminished neural olfactory input which facilitates volume reduction in the insula and STG. The OB volume may hence constitute a factor of vulnerability to depression. Olfactory-based deep brain stimulation is discussed as a future therapeutic approach.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.