Evidence map›Paper›PMID 29492963›Full record

SynthesisInternational dental journal2018

Efficacy of systemic antibiotics in nonsurgical periodontal therapy for diabetic subjects: a systematic review and meta-analysis.

Maria Luisa S Souto, Emanuel S Rovai, Juliana A Ganhito, Marinella Holzhausen, Leandro Chambrone, Cláudio M Pannuti

Abstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in International dental journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 8 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 8 syntheses or guidelines pooled it.

  1. Antibiotics in periodontal treatment: an umbrella review.Frontiers in cellular and infection microbiology · 2025
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  9. Trial
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  11. Article
  12. Review
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  15. Review
  16. Antioxidants (Basel, Switzerland) · 2021
    Review
  17. Antioxidants (Basel, Switzerland) · 2020
    Review
  18. Periodontal Disease in Diabetes Mellitus: A Case-Control Study in Smokers and Non-Smokers.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2020
    Article
  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Maria Luisa S SoutoDivision of Periodontics, School of Dentistry, University of São Paulo, São Paulo, Brazil.
Emanuel S RovaiDivision of Periodontics, School of Dentistry, University of São Paulo, São Paulo, Brazil.
Juliana A GanhitoDivision of Periodontics, School of Dentistry, University of São Paulo, São Paulo, Brazil.
Marinella HolzhausenDivision of Periodontics, School of Dentistry, University of São Paulo, São Paulo, Brazil.
Leandro ChambroneUnit of Basic Oral Investigations, El Bosque University, Bogota, Colombia.
Cláudio M PannutiDivision of Periodontics, School of Dentistry, University of São Paulo, São Paulo, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo evaluate the effects of systemic antibiotics as adjuncts to nonsurgical periodontal treatment (NSPT), as opposed to using NSPT alone, on periodontal clinical parameters of diabetic patients with periodontitis. MATERIALS AND

methodsRandomised controlled trials with a follow-up of 3 months or more, assessing the effects of NSPT in combination with antibiotics, in diabetic patients with periodontitis were included. Trials published up to August 2016 were identified from MEDLINE, EMBASE and LILACS databases. Meta-analyses were conducted to determine changes in clinical attachment level (CAL), probing pocket depth (PPD), bleeding on probing (BOP) and gingival index (GI). Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were followed in this review.

resultsOf the 164 papers potentially admissible to this systematic review, 15 articles on 11 randomised clinical trials were considered as eligible. The results of the meta-analyses presented a modest additional benefit of 0.14 mm (95% confidence interval: 0.08-0.20) in reducing PPD but no further benefit in CAL gain.

conclusionWhen the data for all antibiotic protocols were considered together for the treatment of periodontitis patients with DM, a significant, albeit small, reduction of PPD and no improvement in CAL gain was observed. When the antibiotic protocols were analysed separately, the combination of amoxicillin plus metronidazole yielded the best results for PPD.

Indexed as

AmoxicillinAnti-Bacterial AgentsDental ScalingDiabetes MellitusDoxycyclineDrug Therapy, CombinationHumansMetronidazolePeriodontal DiseasesPeriodontal PocketAmoxicillinAnti-Bacterial AgentsDoxycyclineMetronidazoleanti-infective agentsDiabetes mellitusperiodontal diseasesroot planingsystematic review

Identifiers

PMID29492963
PMCPMC9378894

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.