ArticleCellular oncology (Dordrecht, Netherlands)2018
Inhibition of autophagy enhances DENSpm-induced apoptosis in human colon cancer cells in a p53 independent manner.
Article in Cellular oncology (Dordrecht, Netherlands), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
7 citing papers in PubMed, 12 citations in OpenAlex.
- Targeting Polyamine Metabolism in Colorectal Cancer: Apigenin Dismantles the HIF-1α/SMOX Positive Feedback Loop to Suppress Tumor Progression.International journal of molecular sciences · 2026Article
- Different Roles of Apoptosis and Autophagy in the Development of Human Colorectal Cancer.International journal of molecular sciences · 2023Review
- Autophagy is a double-edged sword in the therapy of colorectal cancer.Oncology letters · 2021Review
- LncRNA SNHG12 promotes the development and progression of colon cancer by regulating the miR-15a/PDK4 axis.American journal of translational research · 2021Article
- MicroRNA-mediated redox regulation modulates therapy resistance in cancer cells: clinical perspectives.Cellular oncology (Dordrecht, Netherlands) · 2019Review
- The multifaceted role of autophagy in cancer and the microenvironment.Medicinal research reviews · 2019Review
- SIRT5-mediated deacetylation of LDHB promotes autophagy and tumorigenesis in colorectal cancer.Molecular oncology · 2019Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
purposeOne of the recently developed polyamine (PA) analogues, N
methodsThe apoptotic effects of DENSpm after 3-MA treatment or Beclin-1 silencing were determined by PI and AnnexinV/PI staining in conjunction with flow cytometry. Intracellular PA levels were measured by HPLC, whereas autophagy and the expression profiles of PA key players were determined in HCT116, SW480 and HT29 colon cancer cells by Western blotting.
resultsWe found that DENSpm-induced autophagy was inhibited by 3-MA treatment and Beclin-1 silencing, and that apoptotic cell death was increased by PA depletion and spermidine/spermine N
conclusionsFrom our results we conclude that DENSpm-induced apoptotic cell death is increased when autophagy is inhibited by 3-MA or Beclin-1 siRNA through PA depletion and PA catabolic activation in colon cancer cells, regardless p53 mutation status.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.