Evidence map›Paper›PMID 29492849›Full record

ArticleMolecular neurobiology2018

Physiological Concentration of Prostaglandin E

Shih-Heng Chen, Yueh-Feng Sung, Esteban A Oyarzabal, Yu-Mei Tan, Jeremy Leonard, Mingri Guo, Shuo Li, Qingshan Wang, Chun-Hsien Chu, Shiou-Lan Chen and 2 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular neurobiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Inhibition of human microsomal PGE2 synthase-1 reduces seizure-induced increases of P-glycoprotein expression and activity at the blood-brain barrier.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 3 countries.

Shih-Heng ChenNeurobiology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, NIEHS/NIH, 111 T.W. Alexander Dr., Research Triangle Park, NC, 27709, USA. chens3@niehs.nih.gov.ORCID http://orcid.org/0000-0002-5853-6903
Yueh-Feng SungNeurobiology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, NIEHS/NIH, 111 T.W. Alexander Dr., Research Triangle Park, NC, 27709, USA.
Esteban A OyarzabalNeurobiology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, NIEHS/NIH, 111 T.W. Alexander Dr., Research Triangle Park, NC, 27709, USA.
Yu-Mei TanU.S. Environmental Protection Agency, National Exposure Research Lab, Research Triangle Park, NC, USA.
Jeremy LeonardOak Ridge Institute for Science and Education, Oak Ridge, TN, USA.
Mingri GuoNeurobiology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, NIEHS/NIH, 111 T.W. Alexander Dr., Research Triangle Park, NC, 27709, USA.
Shuo LiNeurobiology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, NIEHS/NIH, 111 T.W. Alexander Dr., Research Triangle Park, NC, 27709, USA.
Qingshan WangNeurobiology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, NIEHS/NIH, 111 T.W. Alexander Dr., Research Triangle Park, NC, 27709, USA.
Chun-Hsien ChuNeurobiology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, NIEHS/NIH, 111 T.W. Alexander Dr., Research Triangle Park, NC, 27709, USA.
Shiou-Lan ChenDepartment of Neurology, School of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
Ru-Band LuInstitute of Behavioral Medicine, College of Medicine & Hospital, National Cheng Kung University, Tainan, Taiwan.
Jau-Shyong HongNeurobiology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, NIEHS/NIH, 111 T.W. Alexander Dr., Research Triangle Park, NC, 27709, USA. hong3@niehs.nih.gov.
National Institutes of Health · USEnvironmental Protection Agency · USKaohsiung Medical University · TWNational Cheng Kung University · TWOak Ridge Associated Universities · USTri-Service General Hospital · TW

Funding

Intramural NIH HHS Z99 ES999999
6 · The paper itself

Abstract

This study investigated the physiological regulation of brain immune homeostasis in rat primary neuron-glial cultures by sub-nanomolar concentrations of prostaglandin E2 (PGE

Indexed as

Signal TransductionAnimalsAnti-Inflammatory AgentsCell MembraneCells, CulturedChlorocebus aethiopsCOS CellsCytosolDinoprostoneDopaminergic NeuronsFemaleInflammation MediatorsLipopolysaccharidesMice, Inbred C57BLMicrogliaNADPH OxidasesAnti-Inflammatory AgentsDinoprostoneInflammation MediatorsLipopolysaccharidesNADPH OxidasesNeuroprotective AgentsNeurotoxinsProtein SubunitsReceptors, Prostaglandin ESuperoxidesMicrogliaNeuro-inflammationNeuroprotectionNOX2Prostaglandin E2

Identifiers

PMID29492849
PMCPMC6119547
OpenAlexW2790954517

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.