Evidence map›Paper›PMID 29492735›Full record

ArticleBreast cancer research and treatment2018

The risk of cardiovascular disease following breast cancer by Framingham risk score.

Sofie A M Gernaat, Jolanda M A Boer, Desiree H J van den Bongard, Angela H E M Maas, Carmen C van der Pol, Rhodé M Bijlsma, Diederick E Grobbee, Helena M Verkooijen, Petra H Peeters

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In one paragraph

Article in Breast cancer research and treatment, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 1 synthesis or guideline pooled it.

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  16. The intersection of heart failure and cancer in women: a review.Frontiers in cardiovascular medicine · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Sofie A M GernaatDepartment of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Jolanda M A BoerCentre for Nutrition, Prevention and Health Services, National Institute for Public Health and the Environment (RIVM), Utrecht University, Bilthoven, Utrecht, The Netherlands.
Desiree H J van den BongardDepartment of Radiation Oncology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Angela H E M MaasDepartment of Cardiology, Radboud University Medical Center Nijmegen, Nijmegen, The Netherlands.
Carmen C van der PolDepartment of Surgical Oncology, Utrecht University, Utrecht, The Netherlands.
Rhodé M BijlsmaDepartment of Medical Oncology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Diederick E GrobbeeDepartment of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Helena M VerkooijenImaging Division, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands. h.m.verkooijen@umcutrecht.nl.
Petra H PeetersDepartment of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThis study evaluates the risk of cardiovascular disease (CVD) following breast cancer, accounting for baseline CVD risk.

methodsWithin the EPIC-NL (Dutch part of the European Prospective Investigation into Nutrition and Cancer) cohort, 1103 women were diagnosed with breast cancer. For every breast cancer patient, 3-4 women without breast cancer (n = 4328) were selected matched for age, year, and time since cohort enrollment. Based on CVD risk factors at cohort enrollment, 10-year risk of CVD was calculated and categorized: low (< 10%), intermediate (10-20%), high (> 20%). Cox proportional hazard models assessed the risk of CVD events (hospitalization or mortality) and CVD mortality of women with versus without breast cancer, adjusted for baseline CVD risk.

resultsAfter median follow-up of 5 and 6 years, 92 (8.3%) and 325 (7.5%) CVD events occurred in women with and without breast cancer, respectively. In the low CVD risk group, women with breast cancer had 1.44 (95% CI 1.00-2.06) times higher risk of CVD events than women without breast cancer. In the intermediate and high CVD risk categories, risk of CVD events was similar in women with and without breast cancer. Overall, women with breast cancer had 1.77 (95% CI 1.10-2.86) times higher risk of CVD mortality than women without breast cancer.

conclusionsAmong women with low CVD risk, women with breast cancer have a higher risk of CVD event than women without breast cancer. Overall, women with breast cancer have a higher risk of CVD mortality than women without breast cancer.

Indexed as

Longitudinal StudiesAdultAgedBreast NeoplasmsCardiovascular DiseasesCohort StudiesFemaleHumansMiddle AgedProportional Hazards ModelsRisk AssessmentRisk FactorsBreast cancerCardiovascular diseaseMorbidityMortalityRisk

Identifiers

PMID29492735
PMCPMC5993849

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.