Evidence map›Paper›PMID 29492700›Full record

ArticleInternational journal of bipolar disorders2018

Circulating antithyroid antibodies contribute to the decrease of glomerular filtration rate in lithium-treated patients: a longitudinal study.

Alberto Bocchetta, Luca Ambrosiani, Gioia Baggiani, Claudia Pisanu, Caterina Chillotti, Raffaella Ardau, Fernanda Velluzzi, Doloretta Piras, Andrea Loviselli, Antonello Pani

Abstract read
In one paragraph

Article in International journal of bipolar disorders, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Clinical use of lithium salts: guide for users and prescribers.International journal of bipolar disorders · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Alberto BocchettaSection of Neuroscience and Clinical Pharmacology, Department of Biomedical Sciences, University of Cagliari, Via Ospedale 54, 09124, Cagliari, Italy. bocchett@unica.it.
Luca AmbrosianiSection of Neuroscience and Clinical Pharmacology, Department of Biomedical Sciences, University of Cagliari, Via Ospedale 54, 09124, Cagliari, Italy.
Gioia BaggianiSection of Neuroscience and Clinical Pharmacology, Department of Biomedical Sciences, University of Cagliari, Via Ospedale 54, 09124, Cagliari, Italy.
Claudia PisanuSection of Neuroscience and Clinical Pharmacology, Department of Biomedical Sciences, University of Cagliari, Via Ospedale 54, 09124, Cagliari, Italy.
Caterina ChillottiUnit of Clinical Pharmacology, Cagliari University Hospital, Cagliari, Italy.
Raffaella ArdauUnit of Clinical Pharmacology, Cagliari University Hospital, Cagliari, Italy.
Fernanda VelluzziDepartment of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy.
Doloretta PirasNephrology, Dialysis and Transplantation Unit, 'Giuseppe Brotzu' Hospital, Cagliari, Italy.
Andrea LoviselliDepartment of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy.
Antonello PaniNephrology, Dialysis and Transplantation Unit, 'Giuseppe Brotzu' Hospital, Cagliari, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundConcerns about the adverse effects of long-term treatment with lithium include reduced renal function. In the present study, we examined comorbidities which may be associated with chronic kidney disease in a cohort of patients treated with lithium for up to 41 years.

methodsWe studied 394 patients who were treated with lithium for ≥ 5 years. The potential role of comorbidities (diabetes, concurrent antihypertensive medication, treatment with L-thyroxine, and presence of antithyroid peroxidase/microsomes, anti-thyroglobulin, and/or anti-thyrotropin-receptor antibodies) was analysed. We focused on the categories of patients with an estimated glomerular filtration rate (eGFR) lower than 60 or 45 mL/min/1.73 m

resultsAge was associated with a decline to an eGFR lower than 60 mL/min/1.73 m

conclusionsThe present study is the first to suggest a potential role of circulating thyroid antibodies in the severe decline of eGFR in lithium-treated patients.

Indexed as

Anti-thyroglobulinChronicGlomerular filtration rateLithiumRenal insufficiencyThyroid microsomal antibodies

Identifiers

PMID29492700
PMCPMC6161986

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.