ArticlePediatric nephrology (Berlin, Germany)2018
The first hour refill index: a promising marker of volume overload in children and young adults on chronic hemodialysis.
Article in Pediatric nephrology (Berlin, Germany), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Low dialysate sodium in children and young adults on maintenance hemodialysis: a prospective, randomized, crossover study.Pediatric nephrology (Berlin, Germany) · 2023Trial
- Interdialytic weight gain, carotid intima media thickness, and cardiovascular profile in children undergoing chronic hemodialysis: a multicenter study.BMC nephrology · 2026Article
- Technical requirements and devices available for long-term hemodialysis in children-mind the gap!Pediatric nephrology (Berlin, Germany) · 2024Review
- Sodium intake and urinary losses in children on dialysis: a European multicenter prospective study.Pediatric nephrology (Berlin, Germany) · 2023Article
- Nutritional status and volume control in adolescents on chronic hemodialysis.Pediatric nephrology (Berlin, Germany) · 2021Article
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Authors and funding
4 authors.
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Abstract
backgroundVolume overload is a known risk factor for cardiovascular complications in children on hemodialysis (HD), but a measurable index of volume overload is still lacking.
methodsWe propose a novel index of pre-HD volume overload based on blood volume (BV) monitoring, the first hour refill index (RI), calculated as the ratio between the ultrafiltration rate indexed for body weight during the first HD hour and the percent BV change at the first hour of the treatment. This parameter was retrospectively calculated in 121 sessions in 11 oligoanuric children and young adults on chronic HD, with median age 14.3 years (range 5.4-22.4), and its association with left-ventricular mass index, pre-HD blood pressure, and number of antihypertensive medications was evaluated.
resultsThe median RI was 2.07 ml/kg/h/%. There was a significant correlation between RI and median LVMI (r 0.66, p = 0.028), which was 53.4 g/m
conclusionsThe ratio between the ultrafiltration rate per body weight and the BV change during the first hour of a HD session could be a promising index of refill capacity and pre-HD volume overload in children and young adults on chronic HD.
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