ArticleDiabetologia2018
Long-term BMI and growth profiles in offspring of women with gestational diabetes.
Article in Diabetologia, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 1 of them a synthesis that pooled it.
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Who cites it
45 citing papers in PubMed, 1 synthesis or guideline pooled it, 79 citations in OpenAlex.
- The Unrealised Potential for Predicting Pregnancy Complications in Women with Gestational Diabetes: A Systematic Review and Critical Appraisal.International journal of environmental research and public health · 2020Pooled it
- Perinatal and long-term implications of diagnosing gestational diabetes mellitus using only fasting and one-hour post-load glucose concentrations: Secondary analysis of the GEMS trial and its five-year follow-up.Acta obstetricia et gynecologica Scandinavica · 2026Trial
- Prepregnancy body mass index and gestational weight gain are associated with maternal and infant adverse outcomes in Chinese women with gestational diabetes.Scientific reports · 2022Trial
- Metabolic health conditions in pregnancy, human milk hormone concentrations, and infant adiposity.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Review
- Associations Between Gestational Diabetes Mellitus and Neonatal Acyl Metabolic Profiles: An Empirical Study Based on a Birth Cohort.Diabetes, metabolic syndrome and obesity : targets and therapy · 2026Article
- Maternal Pre-Pregnancy Glycemic Status and Growth Delay in Korean Children Aged 18-36 Months: A Population-Based Study.Journal of clinical medicine · 2025Article
- Gestational Diabetes and Obesity: Immediate and Late Sequelae for Offspring.Children (Basel, Switzerland) · 2025Review
- Alterations in newborn metabolite patterns with preterm birth and diabetes in pregnancy.Pediatric research · 2025Article
- Advanced maternal age is a risk factor for both early and late gestational diabetes mellitus: The Japan Environment and Children's Study.Journal of diabetes investigation · 2025Article
- Article
- The Role of METS-IR in Early Screening for Gestational Diabetes Mellitus in Chinese Women: A Two-Center Prospective Study.Diabetes, metabolic syndrome and obesity : targets and therapy · 2025Article
- Assessment of neonatologists' competency in managing gestational diabetes complications: a cross-sectional analysis from China.Frontiers in endocrinology · 2025Article
- Precision stratification of prognostic risk factors associated with outcomes in gestational diabetes mellitus: a systematic review.Communications medicine · 2024Article
- The associations of IGF2, IGF2R and IGF2BP2 gene polymorphisms with gestational diabetes mellitus: A case-control study.PloS one · 2024Article
- Thyroid FT4-to-TSH ratio in the first trimester is associated with gestational diabetes mellitus in women carrying male fetus: a prospective bi-center cohort study.Frontiers in endocrinology · 2024Article
- Gestational diabetes mellitus and linear growth in early childhood.Frontiers in endocrinology · 2024Article
- Platelet counts affect the association between hyperhomocysteinemia and pregnancy complications.BMC public health · 2023Article
- Association between hyperglycaemia in pregnancy and growth of offspring in early childhood: The PANDORA study.Pediatric obesity · 2022Article
- The link between gestational diabetes and cardiovascular diseases: potential role of extracellular vesicles.Cardiovascular diabetology · 2022Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aims/hypothesisGestational diabetes mellitus (GDM) is reported to be associated with childhood obesity, however the magnitude of this association and relation to intrauterine growth is uncertain. We, therefore, aimed to assess whether the growth trajectories of large for gestational age (LGA) and non-LGA offspring of mothers with GDM (OGDM) are different until early adolescence. We also aimed to explore whether growth trajectories of OGDM differ from those of offspring of mothers with type 1 or 2 diabetes (ODM1, ODM2).
methodsWe studied height and BMI standard deviation score (SDS) of the OGDM group, up to the age of 14 years, with subgroup analysis comparing LGA with non-LGA at birth as a reflection of the intrauterine environment. All mothers with GDM who delivered at the University Medical Center Utrecht between 1990 and 2006 were contacted to participate; informed consent was received for 104 OGDM of 93 mothers. Offspring data were collected through Dutch infant welfare centres. Recorded height and weight were converted to BMI and age- and sex-specific SDS values for Dutch children. Additionally, we compared the OGDM group with ODM1 and ODM2 groups in order to identify those offspring with the highest risk of becoming overweight. Growth trajectories were compared between non-LGA and LGA OGDM and between OGDM, ODM1 and ODM2, using a random-effects model. In the longitudinal follow-up a mean of 7.4 ± 2 measurements per infant were available.
resultsMothers had a prepregnancy BMI of 25.8 kg/m CONCLUSIONS/
interpretationUntil early adolescence, OGDM have a BMI that is 0.5 SDS higher than that of the Dutch background population. LGA OGDM appear to be at particularly higher risk of being overweight in adolescence compared with non-LGA OGDM, putting them also at a higher lifetime risk of being overweight and developing obesity. ODM2 showed the highest BMI SDS values and had an average BMI SDS of +1.6 until the age of 14, when it became +2 SD. These results emphasize the importance of adequate recognition and timely treatment of maternal gestational diabetes to prevent fetal macrosomia in obstetrics.
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