Evidence map›Paper›PMID 29492614›Full record

ArticlePsychopharmacology2018

The κ-opioid receptor antagonist JDTic decreases ethanol intake in alcohol-preferring AA rats.

Johanna Uhari-Väänänen, Atso Raasmaja, Pia Bäckström, Ville Oinio, F Ivy Carroll, Mikko Airavaara, Kalervo Kiianmaa, Petteri Piepponen

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In one paragraph

Article in Psychopharmacology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Johanna Uhari-VäänänenDepartment of Pharmacology and Pharmacotherapy, Faculty of Pharmacy, University of Helsinki, P.O. Box 56, 00014, Helsinki, Finland. johanna.uhari@helsinki.fi.ORCID http://orcid.org/0000-0002-6086-3014
Atso RaasmajaDepartment of Pharmacology and Pharmacotherapy, Faculty of Pharmacy, University of Helsinki, P.O. Box 56, 00014, Helsinki, Finland.
Pia BäckströmDepartment of Health, National Institute for Health and Welfare, P.O. Box 30, 00271, Helsinki, Finland.
Ville OinioDepartment of Pharmacology and Pharmacotherapy, Faculty of Pharmacy, University of Helsinki, P.O. Box 56, 00014, Helsinki, Finland.
F Ivy CarrollRTI International, P.O. Box 12194, Research Triangle Park, NC, USA.
Mikko AiravaaraInstitute of Biotechnology, University of Helsinki, P.O. Box 56, 00014, Helsinki, Finland.
Kalervo KiianmaaDepartment of Health, National Institute for Health and Welfare, P.O. Box 30, 00271, Helsinki, Finland.
Petteri PiepponenDepartment of Pharmacology and Pharmacotherapy, Faculty of Pharmacy, University of Helsinki, P.O. Box 56, 00014, Helsinki, Finland.
University of Helsinki · FIFinnish Institute for Health and Welfare · FIRTI International · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

rationaleStudies suggest that the κ-opioidergic system becomes overactivated as ethanol use disorders develop. Nalmefene, a currently approved treatment for ethanol use disorders, may also elicit some of its main effects via the κ-opioidergic system. However, the exact role of κ-opioid receptors on regulating ethanol intake and contribution to the development of ethanol addiction remains to be elucidated.

objectivesThe aim of the present study was to clarify the role of accumbal κ-opioid receptors in controlling ethanol intake in alcohol-preferring Alko Alcohol (AA) rats.

methodsMicroinfusions of the long-acting and selective κ-opioid receptor antagonist JDTic (1-15 μg/site) were administered bilaterally into the nucleus accumbens shell of AA rats voluntarily consuming 10% ethanol solution in the intermittent, time-restricted two-bottle choice access paradigm. JDTic (10 mg/kg) was also administered subcutaneously. Both the acute and long-term effects of the treatment on ethanol intake were examined. As a reference, nor-BNI (3 μg/site) was administered intra-accumbally.

resultsSystemically administered JDTic decreased ethanol intake significantly 2 days and showed a similar trend 4 days after administration. Furthermore, intra-accumbally administered JDTic showed a weak decreasing effect on ethanol intake long-term but had no acute effects. Intra-accumbal administration of nor-BNI tended to decrease ethanol intake.

conclusionsThe results provide further evidence that κ-opioid receptors play a role in controlling ethanol intake and that accumbal κ-opioid receptors participate in the modulation of the reinforcing effects of ethanol. Furthermore, the results suggest that κ-opioid receptor antagonists may be a valuable adjunct in the pharmacotherapy of ethanol use disorders.

Indexed as

Alcohol DrinkingAnimalsEthanolMaleMicroinjectionsNarcotic AntagonistsNucleus AccumbensPiperidinesRatsReceptors, Opioid, kappaReinforcement, PsychologyTetrahydroisoquinolines7-hydroxy-N-(1-((4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl)methyl)-2-methylpropyl)-1,2,3,4-tetrahydro-3-isoquinolinecarboxamideEthanolNarcotic AntagonistsPiperidinesReceptors, Opioid, kappaTetrahydroisoquinolinesAlko Alcohol ratIntermittent ethanol intakeJDTicNor-BNINucleus accumbens shellκ-Opioid receptor

Identifiers

PMID29492614
OpenAlexW2789962349

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.