ArticleUrolithiasis2018
Uric acid stones increase the risk of chronic kidney disease.
Article in Urolithiasis, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 45 citations in OpenAlex.
- Altered gut microbial functional pathways in people with irritable bowel syndrome enable precision health insights.BMC gastroenterology · 2025Article
- Protein Intake and High Uric Acid Stone Risk.Kidney medicine · 2024Article
- Urinary stone analysis and clinical characteristics of 496 patients in Taiwan.Scientific reports · 2024Article
- Risk of incident chronic kidney disease among patients with urolithiasis: a nationwide longitudinal cohort study.Clinical kidney journal · 2024Article
- Article
- Increased risk of chronic kidney disease in uric acid stone formers with high neutrophil-to-lymphocyte ratio.Scientific reports · 2023Article
- Proteomics and transcriptomics profiling reveals distinct aspects of kidney stone related genes in calculi rats.BMC genomics · 2023Article
- Urinary Risk Profile, Impact of Diet, and Risk of Calcium Oxalate Urolithiasis in Idiopathic Uric Acid Stone Disease.Nutrients · 2023Article
- Serum and urine uric acid level may have different predictive value for urinary stone composition: a retrospective cohort study of 718 patients in Chinese population.International urology and nephrology · 2022Article
- Association of Gut Microbiota and Biochemical Features in a Chinese Population With Renal Uric Acid Stone.Frontiers in pharmacology · 2022Article
- Effect Modification of Hyperuricemia, Cardiovascular Risk, and Age on Chronic Kidney Disease in China: A Cross-Sectional Study Based on the China Health and Nutrition Survey Cohort.Frontiers in cardiovascular medicine · 2022Article
- Impact of age and renal function on urine chemistry in patients with calcium oxalate kidney stones.Urolithiasis · 2021Article
- A retrospective study on sex difference in patients with urolithiasis: who is more vulnerable to chronic kidney disease?Biology of sex differences · 2021Article
- Trends in the prevalence of kidney stones in the United States from 2007 to 2016.Urolithiasis · 2021Article
- Risk Factors for Renal Impairment in Adult Patients With Short Bowel Syndrome.Frontiers in nutrition · 2020Article
- Gender and chronic kidney disease in ankylosing spondylitis: a single-center retrospectively study.BMC nephrology · 2019Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this study was to compare the clinical characteristics of uric acid stones and their potential risk for chronic kidney disease (CKD). A total of 401 patients (196 with uric acid stone and 205 without) were enrolled from our database of patients with urolithiasis. We analyzed the clinical demographic features, stone location, urine chemistries, and renal function. There was a significant difference (p < 0.001) between the two groups in terms of age, with the higher mean age in the uric acid group. Patients with uric acid stones had much lower pH of urine (p < 0.001) and higher serum uric acid level (p = 0.002). Notably, those with uric acid stones had worse eGFR than those with non-uric acid stones. Multivariate analysis confirmed that age over 60 years (ORs = 9.19; 95% CI 3.5-24.3), female sex (ORs = 4.01; 95% CI 1.8-9.0), hyperuricemia (ORs = 8.47; 95% CI 1.6-43.5), and uric acid stone (OR = 2.86; 95% CI 1.2-6.7) were the independent predictors of poor prognoses in CKD. Therefore, an association exists between uric acid stones and higher prevalence of CKD. Patients with uric acid stones may need close monitoring of renal function during follow-up.
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