ArticleScience advances2018
The ancestral retinoic acid receptor was a low-affinity sensor triggering neuronal differentiation.
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In one paragraph
Article in Science advances, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 1 pooled it
3.0field-weighted citation impact, top 8% of its field
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.
- Mapping molluscan endocrinology: a systematic and critical appraisal.Biological reviews of the Cambridge Philosophical Society · 2026Pooled it
- Retinoic Acid Receptor γ Is a Ligand-Activated Gatekeeper to Stem Cell Developmental Progression.International journal of molecular sciences · 2026Review
- A thyroid hormone-mediated opsin switch initiates metamorphosis in a proto-vertebrate.Science advances · 2026Article
- Bioinformatic Analyses of the Ataxin-2 Family Since Algae Emphasize Its Small Isoforms, Large Chimerisms, and the Importance of Human Exon 1B as Target of Therapies to Prevent Neurodegeneration.International journal of molecular sciences · 2026Article
- The Emerging Oncogenic Role of RARγ: From Stem Cell Regulation to a Potential Cancer Therapy.International journal of molecular sciences · 2025Review
- Targeting Androgen, Thyroid Hormone, and Vitamin A and D Receptors to Treat Prostate Cancer.International journal of molecular sciences · 2024Review
- Bibliometric analysis of research on retinoic acid in the field of kidney disorders.Frontiers in pharmacology · 2024Review
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- Single metal-organic framework-embedded nanopit arrays: A new way to control neural stem cell differentiation.Science advances · 2022Article
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- The Nereid on the rise: Platynereis as a model system.EvoDevo · 2021Review
- Crosstalk between nitric oxide and retinoic acid pathways is essential for amphioxus pharynx development.eLife · 2021Article
- Expression variations of two retinoid signaling pathway receptors in the rotifer Brachionus calyciflorus exposed to three endocrine disruptors.Ecotoxicology (London, England) · 2021Article
Corrections and comments
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Authors and funding
15 authors at 8 institutions in 5 countries.
Mette Handberg-ThorsagerDevelopmental Biology Unit, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69012 Heidelberg, Germany.ORCID 0000-0002-3908-7233
Juliana Gutierrez-MazariegosMolecular Zoology Team, Institut de Génomique Fonctionnelle de Lyon, Université de Lyon, Université Lyon 1, CNRS, Institut National de la Recherche Agronomique, Ecole Normale Supérieure de Lyon, 46 Allée d'Italie, 69364 Lyon Cedex 07, France.
Stefan T AroldKing Abdullah University of Science and Technology, Center for Computational Bioscience Research, Division of Biological and Environmental Sciences and Engineering, Thuwal 23955-6900, Saudi Arabia.ORCID 0000-0001-5278-0668
Eswar Kumar NadendlaCentre de Biochimie Structurale, Inserm, CNRS, Université de Montpellier, 29 Rue de Navacelles, 34090 Montpellier, France.
Paola Y BertucciDevelopmental Biology Unit, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69012 Heidelberg, Germany.ORCID 0000-0002-4116-7689
Pierre GermainCentre de Biochimie Structurale, Inserm, CNRS, Université de Montpellier, 29 Rue de Navacelles, 34090 Montpellier, France.
Pavel TomançakMax Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307 Dresden, Germany.
Keely PierzchalskiDepartment of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, 20 North Pine Street, Baltimore, MD 21201, USA.ORCID 0000-0002-2456-0382
Jace W JonesDepartment of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, 20 North Pine Street, Baltimore, MD 21201, USA.ORCID 0000-0003-0460-0380
Ricard AlbalatDepartament de Genètica, Microbiologia i Estadística, Institut de Recerca de la Biodiversitat (IRBio), Facultat de Biologia, Universitat de Barcelona, Avinguda Diagonal 643, 08028 Barcelona, Spain.ORCID 0000-0003-0282-9595
Maureen A KaneDepartment of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, 20 North Pine Street, Baltimore, MD 21201, USA.ORCID 0000-0002-5525-9170
William BourguetCentre de Biochimie Structurale, Inserm, CNRS, Université de Montpellier, 29 Rue de Navacelles, 34090 Montpellier, France.
Vincent LaudetMolecular Zoology Team, Institut de Génomique Fonctionnelle de Lyon, Université de Lyon, Université Lyon 1, CNRS, Institut National de la Recherche Agronomique, Ecole Normale Supérieure de Lyon, 46 Allée d'Italie, 69364 Lyon Cedex 07, France.ORCID 0000-0003-4022-4175
Detlev ArendtDevelopmental Biology Unit, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69012 Heidelberg, Germany.ORCID 0000-0001-7833-050X
Michael SchubertSorbonne Universités, Université Pierre et Marie Curie (UPMC) Université Paris 06, CNRS, Laboratoire de Biologie du Développement de Villefranche-sur-Mer, Observatoire Océanologique de Villefranche-sur-Mer, 181 Chemin du Lazaret, 06230 Villefranche-sur-Mer, France.ORCID 0000-0002-2341-712X
Centre National de la Recherche Scientifique · FRUniversity of Maryland, Baltimore · USEuropean Molecular Biology Laboratory · DEUniversité Claude Bernard Lyon 1 · FRHeidelberg University · DEKing Abdullah University of Science and Technology · SAMax Planck Institute of Molecular Cell Biology and Genetics · DEUniversitat de Barcelona · ES
Funding
Molecular determinants of retinoid metabolism in embryonic tissuesR01HD077260 · NICHD · UNIVERSITY OF MARYLAND BALTIMORE · PI KANE, MAUREEN A, MOISE, ALEX RADU · 2014 to 2018
$1.6MNICHD NIH HHS R01 HD077260
Abstract
Retinoic acid (RA) is an important intercellular signaling molecule in vertebrate development, with a well-established role in the regulation of
Indexed as
Cell DifferentiationPhylogenyAnimalsAnnelidaAxonsGene Expression RegulationGene Expression Regulation, DevelopmentalNeuronsProtein DomainsProteolysisReceptors, Retinoic AcidSignal TransductionTretinoinReceptors, Retinoic AcidTretinoin
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What OpenQuestion holds
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LicenceCC BY-NC
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.