ArticleJournal of dentistry (Shiraz, Iran)2018
Low Lymphatic Vessel Density Correlates with Lymph Node Metastasis in Oral Squamous Cell Carcinoma.
Article in Journal of dentistry (Shiraz, Iran), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed, 5 citations in OpenAlex.
- Blocking YAP1-Liprin-β2 interaction impedes metastasis and promotes tumor suppression in head and neck squamous carcinoma.Scientific reports · 2025Article
- Association of lymph vessel density with occult lymph node metastasis and prognosis in oral squamous cell carcinoma.BMC oral health · 2021Article
- Targeting methyltransferase PRMT5 retards the carcinogenesis and metastasis of HNSCC via epigenetically inhibiting Twist1 transcription.Neoplasia (New York, N.Y.) · 2020Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
statement of the problemRegional lymph nodes are the nodes draining lymph from region around the tumor and presence of metastatic tumor in regional lymph nodes is the most important prognostic factor for malignant tumors of epithelial origin. Lymphangiogenesis is associated with an increased incidence of regional lymph nodes metastasis and is possibly an essential step for metastasis. Tumor cells secrete lymphangiogenic cytokines, which results in formation of lymphatic vessels within and around the tumor and act as portals for tumor spread. PURPOSE: The present study aims to investigate and quantify lymphatic vessel density (LVD) in oral squamous cell carcinoma (OSCC) and determine whether LVD can predict the risk of sentinel lymph node metastasis. MATERIAL AND
method50 specimens of OSCC, without and with lymph node metastasis (25 each) along with 25 specimens of normal oral mucosa were assessed and LVD was quantified by D2-40 immunostaining. Discrete hotspots of intratumoral lymphatics were identified in superficial and deep areas in all carcinomas to calculate LVD.
resultsWhen compared to normal mucosa, LVD decreased in the superficial intratumoral areas and decreased further in deep areas. In addition, LVD in the superficial and deep areas of OSCC without nodal metastasis was significantly higher than that in OSCC with nodal metastasis.
conclusionOur study provides evidence that lymphangiogenesis varies within the tumor. Lymphatic vessels are either compressed, collapsed, destroyed or absent in deep intratumoral region. Decrease in LVD predicts cervical lymph node metastasis both in superficial and deep areas. Lymphatics in superficial areas are probably major conduit for nodal metastasis in OSCCs.
Indexed as
Identifiers
29492410PMC5817345W2804188907What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.