ArticleAnnals of cardiothoracic surgery2018
Neonatal heart transplantation.
Article in Annals of cardiothoracic surgery, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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Who cites it
16 citing papers in PubMed, 42 citations in OpenAlex.
- Donor-derived cell-free DNA in solid organ transplantation: analytical considerations, diagnostic performance, and clinical interpretation.Clinical transplantation and research · 2025Review
- Clinical Pig Heart Xenotransplantation-Where Do We Go From Here?Transplant international : official journal of the European Society for Organ Transplantation · 2024Article
- Materials and Design Approaches for a Fully Bioresorbable, Electrically Conductive and Mechanically Compliant Cardiac Patch Technology.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Milestones on the path to clinical pig organ xenotransplantation.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2023Review
- Cardiac xenotransplantation: from concept to clinic.Cardiovascular research · 2023Review
- Will previous palliative surgery for congenital heart disease be detrimental to subsequent pig heart xenotransplantation?Transplant immunology · 2022Article
- Recent Advances in Designing Electroconductive Biomaterials for Cardiac Tissue Engineering.Advanced healthcare materials · 2022Review
- The future of cardiac xenotransplantation.Nature reviews. Cardiology · 2022Article
- Characterization of ABH-subtype donor-specific antibodies in ABO-A-incompatible kidney transplantation.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2021Article
- Unexpected death in children with severe congenital heart defects in Norway 2004-2016.Archives of disease in childhood · 2021Article
- Ethical and practical dilemmas in cardiac transplantation in infants: a literature review.European journal of pediatrics · 2021Review
- Rapid whole genome sequencing impacts care and resource utilization in infants with congenital heart disease.NPJ genomic medicine · 2021Article
- Article
- The immune system in infants: Relevance to xenotransplantation.Pediatric transplantation · 2020Review
- Toward a solution for cardiac failure in the newborn.Xenotransplantation · 2018Review
- Preservation of Cardiac Xenografts in a Model of Infant Human Cardiac Transplantation.XenotransplantationArticle
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neonatal heart transplantation was developed and established in the 1980's as a durable modality of therapy for complex-uncorrectable heart disease. Patients transplanted in the neonatal period have experienced unparalleled long-term survival, better than for any other form of solid-organ transplantation. However, the limited availability of neonatal and young infant donors has restricted the indications and applicability of heart transplantation among newborns in the current era. Indications for heart transplantation include congenital heart disease not amenable to other forms of surgical palliation, and cardiomyopathy, including some primary tumors. Use of ABO-incompatible transplants, and organs with prolonged cold ischemic time or marginal function have all been associated with good outcomes in infants. These extended strategies to increase the donor pool may also someday include donation after determination of circulatory death and the use of anencephalic donors. The operative techniques for donors and recipients of neonatal heart transplantation are unique and have been well-described. Immunosuppression protocols for neonates need not include induction and are largely steroid-free. Newborn and young infant transplant recipients have fewer episodes of rejection, less coronary allograft vasculopathy, less post-transplant lymphoproliferative disease and less renal dysfunction than their older counterparts. Long-term outcomes have been very encouraging in terms of graft survival, patient survival, and quality of life. Our review highlights the history, current indications, techniques and outcomes of heart transplantation in this immunologically-privileged subset of patients.
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Registered trials
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