ReviewAnnals of cardiothoracic surgery2018
Heart transplantation versus left ventricular assist devices as destination therapy or bridge to transplantation for 1-year mortality: a systematic review and meta-analysis.
Review in Annals of cardiothoracic surgery, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 68 citations in OpenAlex.
- Impact of Exercise Modalities on Peripheral and Central Components of Cardiorespiratory Capacity in Heart Transplantation Patients: A Systematic Review and Meta-Analysis.Medicina (Kaunas, Lithuania) · 2021Pooled it
- Pulsatility as a Potential Regulator of Cardiovascular Biology: Molecular, Cellular, and Hemodynamic Remodeling During Continuous-Flow Left Ventricular Assist Device Support and Following Heart Transplantation.International journal of molecular sciences · 2026Review
- Exercise capacity after mechanical circulatory support compared to heart transplant in advanced heart failure.JHLT open · 2026Article
- Transfusion-induced HLA antibodies are short-lived and rarely recur post-heart transplantation: a single-center retrospective study with implications for virtual crossmatching.Frontiers in immunology · 2026Article
- Expression profiles of histone H4K20 methylation and its associated enzymes in mouse cardiac disease and human heart failure.Epigenetics · 2025Article
- Outcome Through the Years of Left-Ventricular Assist Devices Therapy for End-Stage Heart Failure: A Review.Journal of clinical medicine · 2024Review
- Contemporary clinical role of echocardiography in patients with advanced heart failure.Heart failure reviews · 2024Review
- Heart Transplantation and Left Ventricular Assist Devices: Long-Term Prognosis and Effects on Mental Health.Cureus · 2024Review
- Future Prospects of Metabolic and Bariatric Surgery: A Comprehensive Review.Healthcare (Basel, Switzerland) · 2024Review
- Obesity, organ failure, and transplantation: a review of the role of metabolic and bariatric surgery in transplant candidates and recipients.Surgical endoscopy · 2024Review
- Left Ventricular Assist Device as a Destination Therapy: Current Situation and the Importance of Patient Selection.Life (Basel, Switzerland) · 2023Review
- Elevated Plasma Immunoglobulin Levels Prior to Heart Transplantation Are Associated with Poor Post-Transplantation Survival.Biology · 2022Article
- Impact of Left Ventricular Assist Devices on Days Alive and Out of Hospital in Hemodynamically Stable Patients with End-Stage Heart Failure: A Propensity Score Matched Study.Life (Basel, Switzerland) · 2022Article
- Patterns and predictors of dyspnoea following left ventricular assist device implantation.European journal of cardiovascular nursing · 2022Article
- Computational Fluid-Structure Interaction Study of a New Wave Membrane Blood Pump.Cardiovascular engineering and technology · 2022Article
- Effects of the atrium on intraventricular flow patterns during mechanical circulatory support.The International journal of artificial organs · 2022Article
- Management of Patients with Left Ventricular Assist Device during the COVID-19 Pandemic.Medicina (Kaunas, Lithuania) · 2022Review
- Physiologic Data-Driven Iterative Learning Control for Left Ventricular Assist Devices.Frontiers in cardiovascular medicine · 2022Article
- Reciprocal interferences of the left ventricular assist device and the aortic valve competence.Frontiers in cardiovascular medicine · 2022Review
- Ventricular Assist Devices: Challenges of the One-device Era.Cardiac failure review · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe optimal treatment for advanced heart failure (HF) patients with regards to mortality remains unknown. Heart transplantation (HTx) and left ventricular assist devices (LVAD) used either as a bridge to transplant (BTT) or destination therapy (DT) have been compared in a number of studies, without definite conclusions with regards to mortality benefit. We sought to systematically review the pertinent literature and perform a meta-analysis of all the available studies presenting head-to-head comparisons between HTx and LVAD BTT or LVAD DT for late (>6 months) all-cause mortality.
methodsWe performed a systematic search of Medline and Cochrane Central databases in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. We conducted a meta-analysis of late mortality comparing HTx
resultsEight studies were included in our meta-analysis, reporting data on 7,957 patients in total. Although the available studies are of high quality [8 stars in Newcastle-Ottawa Scale (NOS) on average], there is paucity of mortality data. Specifically, seven studies compared HTx with BTT and five studies compared HTx with DT for 1-year mortality. Our pooled estimates showed that there was no difference in late mortality among these strategies.
conclusionsOur meta-analysis highlights the small number and the heterogeneity of available studies referring to the optimal invasive management of advanced HF, and shows that there are no differences between HTx and LVAD for these patients with regards to late mortality.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.