ArticleEnvironmental epigenetics2017
Multigenerational analysis of sex-specific phenotypic differences at midgestation caused by abnormal folate metabolism.
Article in Environmental epigenetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 13 citations in OpenAlex.
- Dietary folic acid prevents peripheral neuropathy in mouse models of neural tube defects and type 2 diabetes.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- One-carbon metabolism is required for epigenetic stability in the mouse placenta.Frontiers in cell and developmental biology · 2023Article
- Article
- Prenatal Choline Supplementation Alters One Carbon Metabolites in a Rat Model of Periconceptional Alcohol Exposure.Nutrients · 2022Article
- Variably methylated retrotransposons are refractory to a range of environmental perturbations.Nature genetics · 2021Article
- Defective folate metabolism causes germline epigenetic instability and distinguishes Hira as a phenotype inheritance biomarker.Nature communications · 2021Article
- Disruption of Folate Metabolism Causes Poor Alignment and Spacing of Mouse Conceptuses for Multiple Generations.Frontiers in cell and developmental biology · 2021Article
- Abnormal folate metabolism causes age-, sex- and parent-of-origin-specific haematological defects in mice.The Journal of physiology · 2018Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The exposure to adverse environmental conditions (e.g. poor nutrition) may lead to increased disease risk in an individual and their descendants. In some cases, the results may be sexually dimorphic. A range of phenotypes has been associated with deficiency in or defective metabolism of the vitamin folate. However, the molecular mechanism linking folate metabolism to development is still not well defined nor is it clear whether phenotypes are sex-specific. The enzyme methionine synthase reductase (MTRR) is required for the progression of folate metabolism and the utilization of methyl groups from the folate cycle. Previously, we showed that the hypomorphic
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Registered trials
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