ArticleEnvironmental epigenetics2017
Cadmium exposure and age-associated DNA methylation changes in non-smoking women from northern Thailand.
Article in Environmental epigenetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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The trial behind it
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.
- Chemical and climatic environmental exposures and epigenetic aging: A systematic review.Environmental research · 2025Pooled it
- Metal carcinogens and cancer: integrating genetic and epigenetic perspectives.Frontiers in oncology · 2026Review
- Environmental Xenobiotics and Epigenetic Modifications: Implications for Human Health and Disease.Journal of xenobiotics · 2025Review
- Association of blood cadmium levels with epigenetic age acceleration in U.S. adults aged > 50 years.Frontiers in public health · 2025Article
- Associations between cadmium exposure and whole-body aging: mediation analysis in the NHANES.BMC public health · 2023Article
- Derivation and validation of an epigenetic frailty risk score in population-based cohorts of older adults.Nature communications · 2022Article
- Serum lead, mercury, manganese, and copper and DNA methylation age among adults in Detroit, Michigan.Environmental epigenetics · 2022Article
- Hypomethylation of LINE-1 retrotransposons is associated with cadmium-induced testicular injury.Environmental science and pollution research international · 2020Article
- Individual species and cumulative mixture relationships of 24-hour urine metal concentrations with DNA methylation age variables in older men.Environmental research · 2020Article
- Cadmium, Smoking, and Human Blood DNA Methylation Profiles in Adults from the Strong Heart Study.Environmental health perspectives · 2020Article
- Article
- DNA Methylation Age-Environmental Influences, Health Impacts, and Its Role in Environmental Epidemiology.Current environmental health reports · 2018Review
- Multi-tissue DNA methylation age: Molecular relationships and perspectives for advancing biomarker utility.Ageing research reviews · 2018Review
Corrections and comments
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Authors and funding
9 authors at 6 institutions in 4 countries.
Funding
Abstract
DNA methylation changes with age, and may serve as a biomarker of aging. Cadmium (Cd) modifies cellular processes that promote aging and disrupts methylation globally. Whether Cd modifies aging processes by influencing establishment of age-associated methylation marks is currently unknown. In this pilot study, we characterized methylation profiles in > 450 000 CpG sites in 40 non-smoking women (age 40-80) differentially exposed to environmental Cd from Thailand. Based on specific gravity adjusted urinary Cd, we classified them as high (HE) and low (LE) exposed and age-matched within 5 years. Urinary Cd was defined as below 2 µg/l in the LE group. We predicted epigenetic age (DNAm-age) using two published methods by Horvath and Hannum and examined the difference between epigenetic age and chronologic age (Δage). We assessed differences by Cd exposure using linear mixed models adjusted for estimated white blood cell proportions, BMI, and urinary creatinine. We identified 213 age-associated CpG sites in our population (
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Registered trials
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