Evidence map›Paper›PMID 29492298›Full record

ArticleEnvironmental epigenetics2016

Adolescent epigenetic profiles and environmental exposures from early life through peri-adolescence.

Jaclyn M Goodrich, Dana C Dolinoy, Brisa N Sánchez, Zhenzhen Zhang, John D Meeker, Adriana Mercado-Garcia, Maritsa Solano-González, Howard Hu, Martha M Téllez-Rojo, Karen E Peterson

Erratum issuedOpen access · goldAbstract read
In one paragraph

Article in Environmental epigenetics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 42 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed, 1 pooled it
3.5field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 1 synthesis or guideline pooled it, 63 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Silicone Wristbands for Measuring Human Exposure to Organic Chemicals: Uses and Benefits for Human Biological Research.American journal of human biology : the official journal of the Human Biology Council · 2026
    Article
  4. Article
  5. EndoCompass Project: Environmental Endocrinology.Hormone research in paediatrics · 2025
    Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 3 countries.

Jaclyn M GoodrichDepartment of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, MI, USA.
Dana C DolinoyDepartment of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, MI, USA.
Brisa N SánchezDepartment of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA.
Zhenzhen ZhangDepartment of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA.
John D MeekerDepartment of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, MI, USA.
Adriana Mercado-GarciaCenter for Research on Nutrition and Health, National Institute of Public Health, Cuernavaca, Morelos, México.
Maritsa Solano-GonzálezCenter for Research on Nutrition and Health, National Institute of Public Health, Cuernavaca, Morelos, México.
Howard HuDalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada.
Martha M Téllez-RojoCenter for Research on Nutrition and Health, National Institute of Public Health, Cuernavaca, Morelos, México.
Karen E PetersonDepartment of Nutritional Sciences, University of Michigan School of Public Health, Ann Arbor, MI, USA.
University of Michigan–Ann Arbor · USNational Institute of Public Health · SIUniversity of Toronto · CA

Funding

Regional Pilot And Feasibility Study Grants ProgramP30DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Scott Soleimanpour · 2013 to 2026
$24.3M
Strategic Vision & Impact on Environmental HealthP30ES017885 · NIEHS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Dana Dolinoy · 2011 to 2026
$21.3M
Stress, Lead, Iron Deficiency and NeurodevelopmentR01ES013744 · NIEHS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Robert O Wright · 2007 to 2026
$13.4M
LEAD DOSE BIOMARKERS, REPRODUCTION, AND INFANT OUTCOMESR01ES007821 · NIEHS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI PETERSON, KAREN EILEEN · 1998 to 2010
$4.7M
Metal Mixtures and NeurodevelopmentR01ES014930 · NIEHS · BRIGHAM AND WOMEN'S HOSPITAL · PI WRIGHT, ROBERT O · 2006 to 2010
$3.2M
Project 1: Prenatal Lead Exposure, Early Childhood Growth, and Sexual MaturationP20ES018171 · NIEHS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI PETERSON, KAREN EILEEN · 2010 to 2012
$584k
NIDDK NIH HHS P30 DK020572NIEHS NIH HHS P20 ES018171NIEHS NIH HHS P30 ES017885NIEHS NIH HHS R01 ES007821NIEHS NIH HHS R01 ES013744NIEHS NIH HHS R01 ES014930
6 · The paper itself

Abstract

Epigenetic perturbations induced by environmental exposures at susceptible lifestages contribute to disease development. Even so, the influence of early life and ongoing exposures on the adolescent epigenome is rarely examined. We examined the association of exposure biomarkers for lead (Pb), bisphenol A (BPA), and nine phthalates metabolites with blood leukocyte DNA methylation at LINE-1 repetitive elements and environmentally responsive genes (

Indexed as

bisphenol Achildhood exposuresDNA methylationleadphthalatesprenatal exposures

Identifiers

PMID29492298
PMCPMC5804533
OpenAlexW2511323040

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.