Evidence map›Paper›PMID 29492258›Full record

ArticleTherapeutic advances in psychopharmacology2018

Benzodiazepine prescription in Ontario residents aged 65 and over: a population-based study from 1998 to 2013.

Simon J C Davies, Binu Jacob, David Rudoler, Juveria Zaheer, Claire de Oliveira, Paul Kurdyak

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PubMed Full text at PMC Publisher
In one paragraph

Article in Therapeutic advances in psychopharmacology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 28 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Simon J C DaviesGeriatric Psychiatry Division, Centre for Addiction and Mental Health, 80 Workman Way, Toronto, ON M6J 1H4, Canada Department of Psychiatry, University of Toronto, Canada.
Binu JacobCentre for Addiction and Mental Health, Toronto, Ontario, Canada.
David RudolerCentre for Addiction and Mental Health, Toronto, Ontario, Canada Institute of Health Policy, Management and Evaluation, University of Toronto, Canada.
Juveria ZaheerCentre for Addiction and Mental Health, Toronto, Ontario, Canada Department of Psychiatry, University of Toronto, Canada.
Claire de OliveiraCentre for Addiction and Mental Health, Toronto, Ontario, Canada Institute of Health Policy, Management and Evaluation, University of Toronto, Canada Institute of Clinical Evaluative Sciences, Toronto, Ontario, Canada.
Paul KurdyakCentre for Addiction and Mental Health, Toronto, Ontario, Canada Department of Psychiatry, University of Toronto, Canada Institute of Health Policy, Management and Evaluation, University of Toronto, Canada Institute of Clinical Evaluative Sciences, Toronto, Ontario, Canada.
Centre for Addiction and Mental Health · CAInstitute for Clinical Evaluative Sciences · CAUniversity of Toronto · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAlthough commonly used in anxiety and insomnia, recent guidelines recommend caution when prescribing benzodiazepines in the elderly. Here we examined rates of benzodiazepine prescribing to older adults in Ontario, Canada from 1998 to 2013 and impact of legislation that made prescribing regulations more strict.

methodAnnual benzodiazepine prescription rates for Ontario residents aged 65 and over were examined using the Ontario Drug Benefit database which captures all publicly funded prescriptions. Since most drugs, including benzodiazepines, are funded for residents aged ⩾65, data are essentially population-based. Weighted least squares regression methods were used to examine trends in prescribing rates (all benzodiazepines, anxiolytics, hypnotics, short- and long-acting drugs and individual drugs) from 1998 to 2013 for all Ontario residents aged ⩾65 and by sex and 5-year age bands. Impact on monthly prescribing rates of legislative changes (November 2011) which aimed to promote appropriate prescribing and dispensing practices for controlled substances, including requiring prescribers to record specified information, was assessed by constructing an interrupted time-series model.

resultsBenzodiazepines were prescribed to 23.2% of the 1,412,638 Ontario residents aged ⩾65 in 1998, declining to 14.9% of 2,057,899 residents aged ⩾65 in 2013 (

conclusionBenzodiazepine prescribing rates declined markedly in this population from 1998 to 2013. Targeted legislation may have reduced rates, but the effect, although statistically significant, was small.

Indexed as

anxietybenzodiazepineinsomniapharmacoepidemiologyregister

Identifiers

PMID29492258
PMCPMC5802639
OpenAlexW2775071978

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.