ArticleOncotarget2018
RNA sequencing reveals widespread transcriptome changes in a renal carcinoma cell line.
Article in Oncotarget, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 26 citations in OpenAlex.
- Based on the gut-heart axis: Polygonum capitatum improves atherosclerosis by modulating gut microbiota and TMAO, supporting MCPIP1/p53-associated endothelial protection.Chinese medicine · 2026Article
- The endonuclease activity of MCPIP1 controls the neoplastic transformation of epithelial cells via the c-Met/CD44 axis.Cell communication and signaling : CCS · 2025Article
- Deciphering the tumour microenvironment of clear cell renal cell carcinoma: Prognostic insights from programmed death genes using machine learning.Journal of cellular and molecular medicine · 2024Article
- The homeostatic function of Regnase-2 restricts neuroinflammation.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2023Article
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- Gene Expression-Based Functional Differences between the Bladder Body and Trigonal Urothelium in Adolescent Female Patients with Micturition Dysfunction.Biomedicines · 2022Article
- Article
- MCPIP1 ribonuclease can bind and cleaveRNA biology · 2021Article
- Integrative genomics reveal a role for MCPIP1 in adipogenesis and adipocyte metabolism.Cellular and molecular life sciences : CMLS · 2020Article
- MCPIP1 RNase and Its Multifaceted Role.International journal of molecular sciences · 2020Review
- Increased expression of CDKN1A/p21 in HIV-1 controllers is correlated with upregulation of ZC3H12A/MCPIP1.Retrovirology · 2020Article
- Transcriptomic Changes in Young Japanese Males After Exposure to Acute Hypobaric Hypoxia.Frontiers in genetics · 2020Article
- Activity of MCPIP1 RNase in tumor associated processes.Journal of experimental & clinical cancer research : CR · 2019Review
- ZC3H12B/MCPIP2, a new active member of the ZC3H12 family.RNA (New York, N.Y.) · 2019Article
- Redefining the Practical Utility of Blood Transcriptome Biomarkers in Inflammatory Bowel Diseases.Journal of Crohn's & colitis · 2019Article
- MCPIP1 regulates the sensitivity of pancreatic beta-cells to cytokine toxicity.Cell death & disease · 2019Article
- Challenges in Stratifying the Molecular Variability of Patient-Derived Colon Tumor Xenografts.BioMed research international · 2018Article
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We used RNA sequencing (RNA-Seq) technology to investigate changes in the transcriptome profile in the Caki-1 clear cell renal cell carcinoma (ccRCC) cells, which overexpress monocyte chemoattractant protein-induced protein 1 (MCPIP1). RNA-Seq data showed changes in 11.6% and 41.8% of the global transcriptome of Caki-1 cells overexpressing wild-type MCPIP1 or its D141N mutant, respectively. Gene ontology and KEGG pathway functional analyses showed that these transcripts encoded proteins involved in cell cycle progression, protein folding in the endoplasmic reticulum, hypoxia response and cell signalling. We identified 219 downregulated transcripts in MCPIP1-expressing cells that were either unchanged or upregulated in D141N-expressing cells. We validated downregulation of 15 transcripts belonging to different functional pathways by qRT-PCR. The growth and viability of MCPIP1-expressing cells was reduced because of elevated p21
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.