Evidence map›Paper›PMID 29492066›Full record

ArticlePakistan journal of medical sciences

Comparison of three formulae for estimation of glomerular filtration rate in severely malnourished children at tertiary care facility.

Misbah Anjum, Khemchand N Moorani, Bilquis Naeem, Shazia Kulsoom, Ashfaq Ahmed Memon

Open access · goldAbstract read
In one paragraph

Article in Pakistan journal of medical sciences. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 78% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Misbah AnjumMisbah Anjum, MBBS, FCPS. Assistant Professor, Dept. of Pediatric Medicine (Unit-III), National Institute of Child Health (NICH), Jinnah Sindh Medical University (JSMU), Karachi, Pakistan.
Khemchand N MooraniProf. Khemchand N. Moorani, FCPS, MCPS, MBBS, Pediatric Nephrology & Medical (Unit-III), National Institute of Child Health (NICH), Jinnah Sindh Medical University (JSMU), Karachi, Pakistan.
Bilquis NaeemBilquis Naeem, MBBS, FCPS. Senior Registrar, Pediatric Nephrology & Medical (Unit-III), National Institute of Child Health (NICH), Jinnah Sindh Medical University (JSMU), Karachi, Pakistan.
Shazia KulsoomShazia Kulsoom, MBBS, FCPS. Senior Registrar, Dept. of Pediatric Medicine (Unit-III), National Institute of Child Health (NICH), Jinnah Sindh Medical University (JSMU), Karachi, Pakistan.
Ashfaq Ahmed MemonAshfaq Ahmed Memon, M. Sc Statistics. Senior Statistical Officer, Pakistan Health Research Centre (PHRC), Specialized Research Centre on Child Health, National Institute of Child Health (NICH), Jinnah Sindh Medical University (JSMU), Karachi, Pakistan.
Jinnah Sindh Medical University · PKNational Institute of Child Health · PK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesFirst objective was to compare eGFR by Updated Schwartz (US) and Simple Height Independent (SHID) formula with Original Schwartz (OS) in children with Severe Acute Malnutrition (SAM). The second objective was to compare eGFR in children below and above two years.

methodsThis analytic study on estimation of GFR was based on retrospective data collected from 78 children with SAM at Nutritional Rehabilitation Unit from October 2014 - March 2015. Glomerular filtration rate was calculated using serum creatinine (S. Cr) and height in Original Schwartz, US and by age in SHID equation and compared with OS as standard. Data was analyzed using descriptive statistics.

resultsThere were 78 children in this study. Males were 39(50%). Mean age of patients was 18±15.53 months with 62(79.48%) ≤24 months. Mean weight, height and Mid Upper Arm Cir-cumference was 5.69±2.42kg, 68.52+13.59 cm and 10±1.57 cm respectively. Mean eGFR by OS, US and SHID formula was 71.45±49.89, 58.06±3.91 and 59.33±3.73ml/min/1.73m2 respectively. There was significant difference (0.001) in mean eGFR calculated by three different formulae. Majority of children (73%) had subnormal GFR (<90 ml/min /1.73 m2). There was a significant difference in GFR ≥90ml calculated by US compared to OS (0.025) and by SHID with OS (0.04) in children below two years and no difference in children above two years. But there was no difference in other categories of eGFR calculated by either of formula in both age groups.

conclusionWe found a significant difference in eGFR in ranges above 90 ml/min/1.73 m2 by US compared to OS as well as by SHID with OS in children below two years and no difference in children above two years. Also, there was no difference in GFR categories below 90 ml/min /1.73 m2 calculated by either of formula in both age groups. So, we may conclude that either of formula can be used in clinical practice for eGFR in mild to severe renal dysfunction in severely malnour-ished children.

Indexed as

eGFR formulaGlomerular filtration rateRenal function impairmentSevere acute malnutrition

Identifiers

PMID29492066
PMCPMC5768832
OpenAlexW2774060953

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.