ArticleCurrent zoology2016
Central monoaminergic systems are a site of convergence of signals conveying the experience of exercise to brain circuits involved in cognition and emotional behavior.
Article in Current zoology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The Effect of Exercise Training on Anxiety Symptoms in Children and Adolescents: A Systematic Review and Meta-Analysis of Randomized Trials.Scandinavian journal of medicine & science in sports · 2025Pooled it
- Key influences on university students' physical activity: a systematic review using the Theoretical Domains Framework and the COM-B model of human behaviour.BMC public health · 2024Pooled it
- Exercise Myokine Irisin Enables Behavioral Stress Resistance in Mice.bioRxiv : the preprint server for biology · 2026Article
- Multiple Sex- and Circuit-Specific Mechanisms Underlie Exercise-Induced Stress Resistance.Current topics in behavioral neurosciences · 2024Review
- Aerobic exercise in the treatment of PTSD: An examination of preclinical and clinical laboratory findings, potential mechanisms, clinical implications, and future directions.Journal of anxiety disorders · 2023Review
- Neurochemical and Cognitive Beneficial Effects of Moderate Physical Activity and Catechin in Aged Rats.Antioxidants (Basel, Switzerland) · 2021Article
- Acute exercise enhances fear extinction through a mechanism involving central mTOR signaling.Neurobiology of learning and memory · 2020Article
- Sex differences in resilience: Experiential factors and their mechanisms.The European journal of neuroscience · 2020Review
- Effects of repeated voluntary or forced exercise on brainstem serotonergic systems in rats.Behavioural brain research · 2020Article
- Physical Exercise and Neuroinflammation in Major Depressive Disorder.Molecular neurobiology · 2019Review
- Voluntary exercise enables stress resistance in females.Behavioural brain research · 2019Article
- Adaptive Changes in the Sensitivity of the Dorsal Raphe and Hypothalamic Paraventricular Nuclei to Acute Exercise, and Hippocampal Neurogenesis May Contribute to the Antidepressant Effect of Regular Treadmill Running in Rats.Frontiers in behavioral neuroscience · 2017Article
- The role of monoamines in modulating behavior.Current zoology · 2016Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Physical activity can enhance cognitive function and increase resistance against deleterious effects of stress on mental health. Enhanced cognitive function and stress resistance produced by exercise are conserved among vertebrates, suggesting that ubiquitous mechanisms may underlie beneficial effects of exercise. In the current review, we summarize the beneficial effects of exercise on cognitive function and stress resistance and discuss central and peripheral signaling factors that may be critical for conferring the effects of physical activity to brain circuits involved in cognitive function and stress. Additionally, it is suggested that norepinephrine and serotonin, highly conserved monoamines that are sensitive to exercise and able to modulate behavior in multiple species, could represent a convergence between peripheral and central exercise signals that mediate the beneficial effects of exercise. Finally, we offer the novel hypothesis that thermoregulation during exercise could contribute to the emotional effects of exercise by activating a subset of temperature-sensitive serotonergic neurons in the dorsal raphe nucleus that convey anxiolytic and stress-protective signals to forebrain regions. Throughout the review, we discuss limitations to current approaches and offer strategies for future research in exercise neuroscience.
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Registered trials
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