ArticleFrontiers in microbiology2018
Oligopeptide Targeting Sortase A as Potential Anti-infective Therapy for
Article in Frontiers in microbiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 54 citations in OpenAlex.
- Molecular basis and therapeutic potential of sortase A inhibitors as new antibiotics against MDR pathogens.Open biology · 2026Review
- Revealing the secrets of quorum sensing: a comprehensive review from signal mechanisms to practical applications.Science China. Life sciences · 2026Review
- Resistance Genes and Virulence Factor Genes in Coagulase-Negative and Positive Staphylococci of theMicroorganisms · 2025Article
- Evaluation of LPRDA Pentapeptide for the Prevention and Treatment ofInternational journal of molecular sciences · 2024Article
- Ensemble Docking as a Tool for the Rational Design of PeptidomimeticInternational journal of molecular sciences · 2024Article
- Harnessing the combined effect of antivirulence agent trans-chalcone with bactericidal curcumin against sortase A enzyme to tackle Gram-positive bacterial infections.Folia microbiologica · 2024Article
- Fraxetin Targeting to Sortase A Decreases the Pathogenicity ofAnimals : an open access journal from MDPI · 2024Article
- Rhein againstCurrent research in food science · 2024Article
- Exploring the modulatory impact of isosakuranetin onVirulence · 2023Article
- Antimicrobial peptidase lysostaphin at subinhibitory concentrations modulates staphylococcal adherence, biofilm formation, and toxin production.BMC microbiology · 2023Article
- Substrate-derived Sortase A inhibitors: targeting an essential virulence factor of Gram-positive pathogenic bacteria.Chemical science · 2023Article
- Self-cyclisation as a general and efficient platform for peptide and protein macrocyclisation.Communications chemistry · 2023Article
- Antimicrobial activities of graphene oxide against biofilm and intracellular Staphylococcus aureus isolated from bovine mastitis.BMC veterinary research · 2023Article
- Functional diversity of staphylococcal surface proteins at the host-microbe interface.Frontiers in microbiology · 2023Review
- Oligopeptide Sortase Inhibitor ModulatesAntibiotics (Basel, Switzerland) · 2022Article
- Theoretical Studies of Leu-Pro-Arg-Asp-Ala Pentapeptide (LPRDA) Binding to Sortase A ofMolecules (Basel, Switzerland) · 2022Article
- Lysine-Targeted Reversible Covalent Ligand Discovery for Proteins via Phage Display.Journal of the American Chemical Society · 2022Article
- Prevalence, Antimicrobial Resistance, and Characterization ofAnimals : an open access journal from MDPI · 2022Article
- Punicalagin, an Inhibitor of Sortase A, Is a Promising Therapeutic Drug to Combat Methicillin-Resistant Staphylococcus aureus Infections.Antimicrobial agents and chemotherapy · 2022Article
- Covalent sortase A inhibitor ML346 preventsRSC medicinal chemistry · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sortase A (SrtA)-catalyzed anchorage of surface proteins in most Gram-positive bacteria is indispensable for their virulence, suggesting that this transpeptidase is a promising target for antivirulence therapy. Here, an oligopeptide, LPRDA, was identified as an effective inhibitor of SrtA via virtual screening based on the LPXTG substrate sequence, and it was found to inhibit SrtA activity
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.