Evidence map›Paper›PMID 29491859›Full record

ArticleFrontiers in microbiology2018

Elucidating Duramycin's Bacterial Selectivity and Mode of Action on the Bacterial Cell Envelope.

Sahar Hasim, David P Allison, Berlin Mendez, Abigail T Farmer, Dale A Pelletier, Scott T Retterer, Shawn R Campagna, Todd B Reynolds, Mitchel J Doktycz

Open access · goldAbstract read
In one paragraph

Article in Frontiers in microbiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.4field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 22 citations in OpenAlex.

  1. Discovery of Coerumycin, a Cinnamycin-like Lantibiotic fromAntibiotics (Basel, Switzerland) · 2026
    Article
  2. Article
  3. Radiolabeling of Platelets withInternational journal of molecular sciences · 2023
    Article
  4. Review
  5. The DedA superfamily member PetA is required for the transbilayer distribution of phosphatidylethanolamine in bacterial membranes.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  6. Article
  7. Article
  8. Formation, characterization and modeling of emergent synthetic microbial communities.Computational and structural biotechnology journal · 2021
    Article
  9. Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Sahar HasimDepartment of Microbiology, University of Tennessee, Knoxville, TN, United States.
David P AllisonBiosciences Division, Oak Ridge National Laboratory, Oak Ridge, TN, United States.
Berlin MendezBiosciences Division, Oak Ridge National Laboratory, Oak Ridge, TN, United States.
Abigail T FarmerDepartment of Chemistry, University of Tennessee, Knoxville, TN, United States.
Dale A PelletierBiosciences Division, Oak Ridge National Laboratory, Oak Ridge, TN, United States.
Scott T RettererBiosciences Division, Oak Ridge National Laboratory, Oak Ridge, TN, United States.
Shawn R CampagnaDepartment of Chemistry, University of Tennessee, Knoxville, TN, United States.
Todd B ReynoldsDepartment of Microbiology, University of Tennessee, Knoxville, TN, United States.
Mitchel J DoktyczBiosciences Division, Oak Ridge National Laboratory, Oak Ridge, TN, United States.
Oak Ridge National Laboratory · USUniversity of Tennessee at Knoxville · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The use of naturally occurring antimicrobial peptides provides a promising route to selectively target pathogenic agents and to shape microbiome structure. Lantibiotics, such as duramycin, are one class of bacterially produced peptidic natural products that can selectively inhibit the growth of other bacteria. However, despite longstanding characterization efforts, the microbial selectivity and mode of action of duramycin are still obscure. We describe here a suite of biological, chemical, and physical characterizations that shed new light on the selective and mechanistic aspects of duramycin activity. Bacterial screening assays have been performed using duramycin and

Indexed as

atomic force microscopy (AFM)cell elasticityduramycinlipidlipidomicsmolecular adhesion forcepeptidoglycanphosphatidylethanolamine (PE)

Identifiers

PMID29491859
PMCPMC5817074
OpenAlexW2793091026

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.