Evidence map›Paper›PMID 29491682›Full record

ArticleWorld journal of gastroenterology2018

Relaxin influences ileal muscular activity through a dual signaling pathway in mice.

Eglantina Idrizaj, Rachele Garella, Fabio Francini, Roberta Squecco, Maria Caterina Baccari

Open access · hybridAbstract read
In one paragraph

Article in World journal of gastroenterology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
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  7. Nitric Oxide: From Gastric Motility to Gastric Dysmotility.International journal of molecular sciences · 2021
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Eglantina IdrizajDepartment of Experimental and Clinical Medicine, Section of Physiological Sciences, University of Florence, Florence 50134, Italy.
Rachele GarellaDepartment of Experimental and Clinical Medicine, Section of Physiological Sciences, University of Florence, Florence 50134, Italy.
Fabio FranciniDepartment of Experimental and Clinical Medicine, Section of Physiological Sciences, University of Florence, Florence 50134, Italy.
Roberta SqueccoDepartment of Experimental and Clinical Medicine, Section of Physiological Sciences, University of Florence, Florence 50134, Italy. roberta.squecco@unifi.it.
Maria Caterina BaccariDepartment of Experimental and Clinical Medicine, Section of Physiological Sciences, University of Florence, Florence 50134, Italy.
University of Florence · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo investigate the signaling pathways involved in the relaxin (RLX) effects on ileal preparations from mice through mechanical and electrophysiological experiments.

methodsFor mechanical experiments, ileal preparations from female mice were mounted in organ baths containing Krebs-Henseleit solution. The mechanical activity was recorded

resultsMechanical experiments showed that RLX induced a decay of the basal tension and a reduction in amplitude of the spontaneous contractions. The effects of RLX were partially reduced by 1H-[1,2,4]oxadiazolo[4,3-

conclusionOur new findings demonstrate that RLX influences ileal muscle through a dual mechanism involving both GC and AC.

Indexed as

AnimalsCalciumCalcium Channels, L-TypeFemaleGastrointestinal MotilityIleumMembrane PotentialsMiceMicroelectrodesModels, AnimalMuscle ContractionMuscle, SmoothMyocytes, Smooth MusclePatch-Clamp TechniquesRelaxinSignal TransductionCalciumCalcium Channels, L-TypeRelaxinAC/cAMPGastrointestinal motilityGC/cGMPRelaxinSmooth muscle

Identifiers

PMID29491682
PMCPMC5829152
OpenAlexW2788553014

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.