Evidence map›Paper›PMID 29491476›Full record

ArticleScientific reports2018

Stromal C-type lectin receptor COLEC12 integrates H. pylori, PGE2-EP2/4 axis and innate immunity in gastric diseases.

Lin-Li Chang, Wen-Hung Hsu, Mou-Chieh Kao, Chih-Chung Chou, Chung-Cheng Lin, Chung-Jung Liu, Bi-Chuang Weng, Fu-Chen Kuo, Chao-Hung Kuo, Ming-Hong Lin and 4 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
3.8field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 38 citations in OpenAlex.

  1. Article
  2. Article
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  4. Article
  5. Article
  6. IL-17A in gastric carcinogenesis: good or bad?Frontiers in immunology · 2024
    Review
  7. Review
  8. Article
  9. Article
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  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Long-TermMicroorganisms · 2020
    Article
  18. Article
  19. Article
  20. Immune and microRNA responses toWorld journal of gastroenterology · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 8 institutions in 1 country.

Lin-Li ChangDepartment of Microbiology and Immunology, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
Wen-Hung HsuGraduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
Mou-Chieh KaoInstitute of Molecular Medicine, National Tsing Hua University, Hsinchu, Taiwan.
Chih-Chung ChouDepartment of Microbiology and Immunology, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
Chung-Cheng LinGraduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
Chung-Jung LiuDivision of Gastroenterology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.
Bi-Chuang WengDivision of Gastroenterology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.
Fu-Chen KuoSchool of Medicine, College of Medicine, E-Da Hospital, I-Shou University, Kaohsiung, Taiwan.
Chao-Hung KuoGraduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
Ming-Hong LinDepartment of Microbiology and Immunology, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
Chun-Jen WangInstitute of Molecular Medicine, National Tsing Hua University, Hsinchu, Taiwan.
Chun-Hung LinChemical Biology and Molecular Biophysics, Taiwan International Graduate Program and the Institute of Biological Chemistry, Academia Sinica, Taipei, Taiwan.
Deng-Chyang WuGraduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan. dechwu@yahoo.com.
Shau-Ku HuangNational Institute of Environmental Health Sciences, National Health Research Institutes, Miaoli, 35053, Taiwan. skhuang@nhri.org.tw.
Kaohsiung Medical University · TWKaohsiung Medical University Chung-Ho Memorial Hospital · TWNational Tsing Hua University · TWE-Da Hospital · TWInstitute of Biological Chemistry, Academia Sinica · TWNational Health Research Institutes · TWNational Taiwan University · TWNational Yang Ming Chiao Tung University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tissue stroma is known to be important in regulating Hp-mediated inflammation, but its interaction with Hp and dendritic cells (DCs) remains to be determined. To this end, the potential crosstalk between H. pylori (Hp) infected gastric stromal cells (Hp-GSCs) and DCs was investigated. Primary GSCs from cancerous and adjacent normal tissues were generated from gastric cancer patients, and monocyte-derived DCs were obtained from healthy individuals. Levels of cytokines and prostaglandin E

Indexed as

Immunity, InnateCD4-Positive T-LymphocytesCollectinsDendritic CellsDinoprostoneGene Expression Regulation, NeoplasticHelicobacter pyloriHumansInterleukin-23Receptors, Prostaglandin E, EP2 SubtypeReceptors, Prostaglandin E, EP4 SubtypeReceptors, ScavengerStomach NeoplasmsStromal CellsTh17 CellsCOLEC12 protein, humanCollectinsDinoprostoneInterleukin-23PTGER2 protein, humanReceptors, Prostaglandin E, EP2 SubtypeReceptors, Prostaglandin E, EP4 SubtypeReceptors, Scavenger

Identifiers

PMID29491476
PMCPMC5830506
OpenAlexW2805724007

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.