Evidence map›Paper›PMID 29491182›Full record

ReviewJournal of the Royal Society, Interface2018

An update on smart biocatalysts for industrial and biomedical applications.

Akhilesh Kumar Shakya, Kutty Selva Nandakumar

Open access · bronzeAbstract readReview
In one paragraph

Review in Journal of the Royal Society, Interface, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 46 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Thermoresponsive Poly(Polymers · 2021
    Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 3 countries.

Akhilesh Kumar ShakyaChemical Engineering Department, Texas Tech University, Lubbock, TX, USA akhilesh.shakya@ttu.edu.ORCID 0000-0002-8907-7009
Kutty Selva NandakumarSchool of Pharmaceutical Sciences, Southern Medical University, Guangzhou, People's Republic of China nandakumar@smu.edu.cn.ORCID 0000-0001-7790-8197
Karolinska Institutet · SETexas Tech University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recently, smart biocatalysts, where enzymes are conjugated to stimuli-responsive (smart) polymers, have gained significant attention. Based on the presence or absence of external stimuli, the polymer attached to the enzyme changes its conformation to protect the enzyme from the external environment and regulate the enzyme activity, thus acting as a molecular switch. Owing to this behaviour, smart biocatalysts can be separated easily from a reaction mixture and re-used several times. Several such smart polymer-based biocatalysts have been developed for industrial and biomedical applications. In addition, they have been used in biosensors, biometrics and nano-electronic devices. This review article covers recent advances in developing different kinds of stimuli-responsive enzyme bioconjugates, including conjugation strategies, and their applications.

Indexed as

BiocatalysisBiosensing TechniquesElectrical Equipment and SuppliesNanotechnologyEnzymes, ImmobilizedHumansEnzymes, Immobilizedindustrial biocatalystmagnetic smart biocatalystresponsive polymersmart biocatalysttherapeutic biocatalystthermo-responsive biocatalyst

Identifiers

PMID29491182
PMCPMC5832743
OpenAlexW2788941685

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.