Evidence map›Paper›PMID 29491133›Full record

ArticleGenes & development2018

Neuronal regulation of longevity by staying cool.

Chih-Chun J Lin, Isaiah A A Neve, Meng C Wang

Abstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes & development, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Short-Term Mild Temperature-Stress-Induced Alterations in theInternational journal of molecular sciences · 2020
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Chih-Chun J LinDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA.
Isaiah A A NeveDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA.
Meng C WangDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA.

Funding

PROGRAM IN HUMAN MOLECULAR GENETICST32GM008307 · NIGMS · BAYLOR COLLEGE OF MEDICINE · PI SHAULSKY, GAD · 1990 to 2020
$6.6M
Decode the chemical language that orchestrates cellular and organismal homeostasisDP1DK113644 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI WANG, MENG CARLA · 2016 to 2020
$5.5M
Prebiotic Regulation of LongevityR01AT009050 · NCCIH · BAYLOR COLLEGE OF MEDICINE · PI WANG, MENG CARLA · 2016 to 2020
$2.6M
LIPID SIGNALING IN REGULATION OF LONGEVITYR01AG045183 · NIA · BAYLOR COLLEGE OF MEDICINE · PI WANG, MENG CARLA · 2013 to 2017
$1.8M
Howard Hughes Medical InstituteNCCIH NIH HHS R01 AT009050NIA NIH HHS R01 AG045183NIDDK NIH HHS DP1 DK113644NIGMS NIH HHS T32 GM008307
6 · The paper itself

Abstract

Aging is fundamental to life and reflects functional declines in different tissues at the organismal level. As a systematic process, aging can be influenced by the interplay between genetic and environmental factors, and the nervous system plays a crucial role in this regulation. Environmental inputs can be sensed by the nervous system, which consequently triggers signaling outputs toward peripheral tissues to regulate gene expression systematically. Thus, understanding the underlying molecular mechanisms behind environmentally triggered neuron-periphery cross-talk is crucial for the promotion of an organism's health and longevity.

Indexed as

Caenorhabditis elegansCaenorhabditis elegans ProteinsAnimalsBrainLongevityNeuronsCaenorhabditis elegans ProteinsagingC. eleganslongevity

Identifiers

PMID29491133
PMCPMC5859961

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.