Evidence map›Paper›PMID 29491011›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2018

Celecoxib Ameliorates Seizure Susceptibility in Autosomal Dominant Lateral Temporal Epilepsy.

Lin Zhou, Liang Zhou, Li-da Su, Sheng-Long Cao, Ya-Jun Xie, Na Wang, Chong-Yu Shao, Ya-Nan Wang, Jia-Huan Zhou, John K Cowell and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 60 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Rescue of Normal Excitability in LGI1-Deficient Epileptic Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023
    Article
  7. eNeuro · 2023
    Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. A NovelInternational journal of molecular sciences · 2021
    Article
  13. Article
  14. Article
  15. Cytosolic phospholipase A2 is a key regulator of blood-brain barrier function in epilepsy.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019
    Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Lin ZhouDepartment of Neurobiology, Key Laboratory of Medical Neurobiology of Zhejiang Province, Zhejiang University School of Medicine, Hangzhou 310058, China.ORCID 0000-0003-1501-2883
Liang ZhouDepartment of Neurobiology, Key Laboratory of Medical Neurobiology of Zhejiang Province, Zhejiang University School of Medicine, Hangzhou 310058, China.
Li-da SuNeuroscience Care Unit.ORCID 0000-0002-3970-5193
Sheng-Long CaoDepartment of Neurobiology, Key Laboratory of Medical Neurobiology of Zhejiang Province, Zhejiang University School of Medicine, Hangzhou 310058, China.
Ya-Jun XieDepartment of Neurobiology, Key Laboratory of Medical Neurobiology of Zhejiang Province, Zhejiang University School of Medicine, Hangzhou 310058, China.ORCID 0000-0003-2988-2708
Na WangDepartment of Neurobiology, Key Laboratory of Medical Neurobiology of Zhejiang Province, Zhejiang University School of Medicine, Hangzhou 310058, China.
Chong-Yu ShaoDepartment of Neurobiology, Key Laboratory of Medical Neurobiology of Zhejiang Province, Zhejiang University School of Medicine, Hangzhou 310058, China.
Ya-Nan WangDepartment of Neurobiology, Key Laboratory of Medical Neurobiology of Zhejiang Province, Zhejiang University School of Medicine, Hangzhou 310058, China.
Jia-Huan ZhouDepartment of Neurobiology, Key Laboratory of Medical Neurobiology of Zhejiang Province, Zhejiang University School of Medicine, Hangzhou 310058, China.
John K CowellDepartment of Neurobiology, Key Laboratory of Medical Neurobiology of Zhejiang Province, Zhejiang University School of Medicine, Hangzhou 310058, China.
Ying ShenDepartment of Neurobiology, Key Laboratory of Medical Neurobiology of Zhejiang Province, Zhejiang University School of Medicine, Hangzhou 310058, China, yshen@zju.edu.cn.
Zhejiang University · CNAugusta University Health · USCARE USA · USSecond Affiliated Hospital of Zhejiang University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Autosomal dominant lateral temporal epilepsy (ADLTE) is an inherited syndrome caused by mutations in the leucine-rich glioma inactivated 1 (LGI1) gene. It is known that glutamatergic transmission is altered in LGI1 mutant mice, and seizures can be reduced by restoring LGI1 function. Yet, the mechanism underlying ADLTE is unclear. Here, we propose that seizures in male

Indexed as

Action PotentialsAnimalsAnticonvulsantsCelecoxibCells, CulturedCerebral CortexCyclooxygenase 2Cyclooxygenase 2 InhibitorsEpilepsy, Temporal LobeIntracellular Signaling Peptides and ProteinsKv1.2 Potassium ChannelMaleMicePhospholipases A2ProteinsPyramidal CellsAnticonvulsantsCelecoxibCyclooxygenase 2Cyclooxygenase 2 InhibitorsIntracellular Signaling Peptides and ProteinsKv1.2 Potassium ChannelLgi1 protein, mousePhospholipases A2ProteinsADLTEcelecoxibCox2epilepsyKv1.2

Identifiers

PMID29491011
PMCPMC5884462
OpenAlexW2788830421

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.