Evidence map›Paper›PMID 29491008›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2018

Circulating Exosomes with Distinct Properties during Chronic Lung Allograft Rejection.

Muthukumar Gunasekaran, Monal Sharma, Ramsey Hachem, Ross Bremner, Michael A Smith, Thalachallour Mohanakumar

Open access · bronzeAbstract read
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed
3.5field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 67 citations in OpenAlex.

  1. Review
  2. Exosomes as a biomarker in postoperative complications: a literature review.Frontiers in cell and developmental biology · 2026
    Review
  3. Review
  4. Extracellular Vesicles and Immune Activation in Solid Organ Transplantation: The Impact of Immunosuppression.BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy · 2025
    Review
  5. Adenosine triphosphate-mediated signaling of P2X7 receptors controls donor extracellular vesicle release and major histocompatibility complex cross-decoration after allotransplantation.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2025
    Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Xenorecognition and costimulation of porcine endothelium-derived extracellular vesicles in initiating human porcine-specific T cell immune responses.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2023
    Article
  12. Article
  13. Review
  14. Review
  15. Review
  16. Extracellular Vesicles in Transplantation.Frontiers in immunology · 2022
    Review
  17. ExtracellularFrontiers in bioengineering and biotechnology · 2022
    Review
  18. Review
  19. Article
  20. Restrictive allograft syndrome vs bronchiolitis obliterans syndrome: Immunological and molecular characterization of circulating exosomes.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Muthukumar GunasekaranNorton Thoracic Institute Research Laboratory, St. Joseph's Hospital and Medical Center, Phoenix, AZ 85013.
Monal SharmaNorton Thoracic Institute Research Laboratory, St. Joseph's Hospital and Medical Center, Phoenix, AZ 85013.
Ramsey HachemDivision of Pulmonary and Critical Care Medicine, Washington University School of Medicine, St. Louis, MO 63110; and.
Ross BremnerDivision of Thoracic Surgery and Lung Transplantation, St. Joseph's Hospital and Medical Center, Phoenix, AZ 85013.
Michael A SmithDivision of Thoracic Surgery and Lung Transplantation, St. Joseph's Hospital and Medical Center, Phoenix, AZ 85013.
Thalachallour MohanakumarNorton Thoracic Institute Research Laboratory, St. Joseph's Hospital and Medical Center, Phoenix, AZ 85013; tm.kumar@dignityhealth.org.ORCID 0000-0001-9873-4018
St. Joseph's Hospital and Medical Center · USWashington University in St. Louis · US

Funding

IMMUNE MECHANISMS OF REJECTION IN HUMAN LUNG ALLOGRAFTSR01HL056643 · NHLBI · WASHINGTON UNIVERSITY · PI MOHANAKUMAR, THALACHALLOUR · 1996 to 2015
$6.5M
ALLOANTIBODIES TO MHC INDUCES AUTOIMMUNITY AND OBLITERATIVE AIRWAY DISEASE (OAD)R01HL092514 · NHLBI · WASHINGTON UNIVERSITY · PI MOHANAKUMAR, THALACHALLOUR · 2009 to 2018
$3.0M
EXOSOMES: ROLE IN ALLOGRAFT REJECTION AND POTENTIAL AS A BIOMARKERR21AI123034 · NIAID · ST. JOSEPH'S HOSPITAL AND MEDICAL CENTER · PI MOHANAKUMAR, THALACHALLOUR · 2016 to 2017
$397k
NHLBI NIH HHS R01 HL056643NHLBI NIH HHS R01 HL092514NIAID NIH HHS R21 AI123034
6 · The paper itself

Abstract

Circulating exosomes containing donor HLA and lung-associated self-antigens (SAg) are thought to play an important role in allograft rejection after human lung transplantation. We characterized exosomes isolated from serum of 10 lung transplant recipients (LTxR) diagnosed with bronchiolitis obliterans syndrome (BOS) and compared them with exosomes isolated from serum of 10 stable LTxR. Lung-associated SAg (K-α-1-tubulin [Kα1T] and collagen V [Col-V]), MHC class II molecules, costimulatory molecules CD40, CD80, and CD86, and transcription factors class II MHC

Indexed as

AllograftsAnimalsAutoantigensBronchiolitis ObliteransExosomesFemaleGraft RejectionHistocompatibility Antigens Class IIHumansInterleukin-17IsoantigensLungLung TransplantationMaleMiceMice, Inbred C57BLAutoantigensHistocompatibility Antigens Class IIInterleukin-17Isoantigens

Identifiers

PMID29491008
PMCPMC5893384
OpenAlexW2788400920

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.