Evidence map›Paper›PMID 29490936›Full record

ArticleThe Journal of experimental medicine2018

STAT-3-independent production of IL-17 by mouse innate-like αβ T cells controls ocular infection.

Anthony J St Leger, Anna M Hansen, Hatice Karauzum, Reiko Horai, Cheng-Rong Yu, Arian Laurence, Katrin D Mayer-Barber, Phyllis Silver, Rafael Villasmil, Charles Egwuagu and 2 more

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of experimental medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. TNF plays a crucial role in inflammation by signaling via T cell TNFR2.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Frontiers in veterinary science · 2020
    Article
  13. Distinct PLZFJournal of immunology (Baltimore, Md. : 1950) · 2019
    Article
  14. Article
  15. Article
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Anthony J St LegerLaboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD.
Anna M HansenLaboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD.ORCID 0000-0002-1192-9435
Hatice KarauzumLaboratory of Clinical Infectious Diseases, National Institutes of Health, Bethesda, MD.
Reiko HoraiLaboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD.
Cheng-Rong YuLaboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD.
Arian LaurenceMolecular Immunology and Inflammation Branch, National Institute of Arthritis, Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD.
Katrin D Mayer-BarberLaboratory of Clinical Immunology and Microbiology, Inflammation and Innate Immunity, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD.
Phyllis SilverLaboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD.
Rafael VillasmilLaboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD.
Charles EgwuaguLaboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD.
Sandip K DattaLaboratory of Clinical Infectious Diseases, National Institutes of Health, Bethesda, MD.
Rachel R CaspiLaboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD caspir@mail.nih.gov.ORCID 0000-0002-7140-7671
National Institutes of Health · US

Funding

T-CELL LINES AND CLONES IN UVEITAZ01EY000184 · NEI · NATIONAL EYE INSTITUTE · PI CASPI, RACHEL R. · 1985 to 2008
$6.6M
Microbiome-dependent modulation of ocular immunity and the implications for infectious R00EY025761 · NEI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ST LEGER, ANTHONY J · 2018 to 2020
$862k
Intramural NIH HHS Z01 EY000184NEI NIH HHS R00 EY025761
6 · The paper itself

Abstract

Appropriate regulation of IL-17 production in the host can mean the difference between effective control of pathogens and uncontrolled inflammation that causes tissue damage. Investigation of conventional CD4

Indexed as

Immunity, InnateAnimalsEye InfectionsImmunologic MemoryInterleukin-17InterleukinsMice, Inbred C57BLMice, KnockoutMucous MembraneNuclear Receptor Subfamily 1, Group F, Member 3PhosphorylationPromyelocytic Leukemia Zinc Finger ProteinReceptors, Antigen, T-Cell, alpha-betaSignal TransductionStaphylococcus aureusSTAT3 Transcription FactorInterleukin-17InterleukinsNuclear Receptor Subfamily 1, Group F, Member 3Promyelocytic Leukemia Zinc Finger ProteinReceptors, Antigen, T-Cell, alpha-betaSTAT3 Transcription FactorZbtb16 protein, mouse

Identifiers

PMID29490936
PMCPMC5881461
OpenAlexW2791561402

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.