Evidence map›Paper›PMID 29490919›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2018

MLH1-rheMac hereditary nonpolyposis colorectal cancer syndrome in rhesus macaques.

David W Brammer, Patrick J Gillespie, Mei Tian, Daniel Young, Muthuswamy Raveendran, Lawrence E Williams, Mihai Gagea, Fernando J Benavides, Carlos J Perez, Russell R Broaddus and 11 more

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
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  8. A nonhuman primate model of inherited retinal disease.The Journal of clinical investigation · 2019
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 7 institutions in 1 country.

David W BrammerDepartment of Veterinary Medicine and Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX 77030.
Patrick J GillespieDepartment of Experimental Diagnostic Imaging, The University of Texas MD Anderson Cancer Center MD Anderson Cancer Center, Houston, TX 77030.
Mei TianDepartment of Experimental Diagnostic Imaging, The University of Texas MD Anderson Cancer Center MD Anderson Cancer Center, Houston, TX 77030.
Daniel YoungDepartment of Experimental Diagnostic Imaging, The University of Texas MD Anderson Cancer Center MD Anderson Cancer Center, Houston, TX 77030.
Muthuswamy RaveendranHuman Genome Sequencing Center, Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030.
Lawrence E WilliamsKeeling Center for Comparative Medicine and Research, The University of Texas MD Anderson Cancer Center MD Anderson Cancer Center, Bastrop, TX 78602.
Mihai GageaDepartment of Veterinary Medicine and Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX 77030.
Fernando J BenavidesDepartment of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center MD Anderson Cancer Center, Smithville, TX 78957.
Carlos J PerezDepartment of Pathology, The University of Texas MD Anderson Cancer Center MD Anderson Cancer Center, Houston, TX 77030.
Russell R BroaddusDepartment of Pathology, The University of Texas MD Anderson Cancer Center MD Anderson Cancer Center, Houston, TX 77030.
Bruce J BernackyKeeling Center for Comparative Medicine and Research, The University of Texas MD Anderson Cancer Center MD Anderson Cancer Center, Bastrop, TX 78602.
Kirstin F BarnhartKeeling Center for Comparative Medicine and Research, The University of Texas MD Anderson Cancer Center MD Anderson Cancer Center, Bastrop, TX 78602.
Mian M AlauddinDepartment of Experimental Diagnostic Imaging, The University of Texas MD Anderson Cancer Center MD Anderson Cancer Center, Houston, TX 77030.
Manoop S BhutaniDepartment of Gastroenterology, Hepatology and Nutrition, The University of Texas MD Anderson Cancer Center MD Anderson Cancer Center, Houston, TX 77030.
Richard A GibbsHuman Genome Sequencing Center, Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030.
Richard L SidmanDepartment of Neurology, Harvard Medical School, Boston, MA 02115; richard_sidman@hms.harvard.edu juri.gelovani@wayne.edu.
Renata PasqualiniRutgers Cancer Institute of New Jersey at University Hospital, Newark, NJ 07103.
Wadih ArapRutgers Cancer Institute of New Jersey at University Hospital, Newark, NJ 07103.
Jeffrey RogersHuman Genome Sequencing Center, Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030.
Christian R AbeeKeeling Center for Comparative Medicine and Research, The University of Texas MD Anderson Cancer Center MD Anderson Cancer Center, Bastrop, TX 78602.
Juri G GelovaniDepartment of Experimental Diagnostic Imaging, The University of Texas MD Anderson Cancer Center MD Anderson Cancer Center, Houston, TX 77030; richard_sidman@hms.harvard.edu juri.gelovani@wayne.edu.
The University of Texas MD Anderson Cancer Center · USBaylor Genetics · USBaylor College of Medicine · USHarvard University · USRutgers New Jersey Medical SchoolThe Barbara Ann Karmanos Cancer Institute · USUniversity Hospital, Newark · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Over the past two decades, 33 cases of colonic adenocarcinomas have been diagnosed in rhesus macaques (

Indexed as

Macaca mulattaAnimalsColorectal Neoplasms, Hereditary NonpolyposisFemaleMaleMicrosatellite InstabilityMutL Protein Homolog 1Polymorphism, Single NucleotidePositron Emission Tomography Computed TomographyPrimate DiseasesMutL Protein Homolog 1colon carcinomahereditaryMLH1rhesus macaquesingle-nucleotide polymorphism

Identifiers

PMID29490919
PMCPMC5856559
OpenAlexW2790803947

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.