Evidence map›Paper›PMID 29490912›Full record

ArticleNeurology2018

Epilepsy, antiepileptic drugs, and serious transport accidents: A nationwide cohort study.

Heléne E K Sundelin, Zheng Chang, Henrik Larsson, Paul Lichtenstein, Catarina Almqvist, Torbjörn Tomson, Jonas F Ludvigsson

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
4.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 49 citations in OpenAlex.

  1. Review
  2. Article
  3. Observational
  4. Antipsychotic treatment adherence and motor vehicle crash among drivers with schizophrenia: a case-crossover study.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2025
    Article
  5. Review
  6. Article
  7. Article
  8. Driving performance of patients with epilepsy undergoing antiepileptic monotherapy.PCN reports : psychiatry and clinical neurosciences · 2023
    Article
  9. Causes of fatalities in motor vehicle occupants: an overview.Forensic science, medicine, and pathology · 2022
    Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. Review
  15. Article
  16. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Heléne E K SundelinFrom the Department of Pediatrics (H.E.K.S.), Linköping University Hospital; Departments of Medical Epidemiology and Biostatistics (Z.C., H.L., P.L., C.A., J.F.L.) and Clinical Neuroscience (T.T.), Karolinska Institutet; Astrid Lindgren Children's Hospital (C.A.), Karolinska University Hospital, Stockholm; Department of Pediatrics (J.F.L.), Örebro University Hospital, Sweden; Division of Epidemiology and Public Health, School of Medicine (J.F.L.), University of Nottingham, UK; and Department of Medicine (J.F.L.), Columbia University, New York, NY. helene.sundelin@hotmail.com.
Zheng ChangFrom the Department of Pediatrics (H.E.K.S.), Linköping University Hospital; Departments of Medical Epidemiology and Biostatistics (Z.C., H.L., P.L., C.A., J.F.L.) and Clinical Neuroscience (T.T.), Karolinska Institutet; Astrid Lindgren Children's Hospital (C.A.), Karolinska University Hospital, Stockholm; Department of Pediatrics (J.F.L.), Örebro University Hospital, Sweden; Division of Epidemiology and Public Health, School of Medicine (J.F.L.), University of Nottingham, UK; and Department of Medicine (J.F.L.), Columbia University, New York, NY.
Henrik LarssonFrom the Department of Pediatrics (H.E.K.S.), Linköping University Hospital; Departments of Medical Epidemiology and Biostatistics (Z.C., H.L., P.L., C.A., J.F.L.) and Clinical Neuroscience (T.T.), Karolinska Institutet; Astrid Lindgren Children's Hospital (C.A.), Karolinska University Hospital, Stockholm; Department of Pediatrics (J.F.L.), Örebro University Hospital, Sweden; Division of Epidemiology and Public Health, School of Medicine (J.F.L.), University of Nottingham, UK; and Department of Medicine (J.F.L.), Columbia University, New York, NY.
Paul LichtensteinFrom the Department of Pediatrics (H.E.K.S.), Linköping University Hospital; Departments of Medical Epidemiology and Biostatistics (Z.C., H.L., P.L., C.A., J.F.L.) and Clinical Neuroscience (T.T.), Karolinska Institutet; Astrid Lindgren Children's Hospital (C.A.), Karolinska University Hospital, Stockholm; Department of Pediatrics (J.F.L.), Örebro University Hospital, Sweden; Division of Epidemiology and Public Health, School of Medicine (J.F.L.), University of Nottingham, UK; and Department of Medicine (J.F.L.), Columbia University, New York, NY.
Catarina AlmqvistFrom the Department of Pediatrics (H.E.K.S.), Linköping University Hospital; Departments of Medical Epidemiology and Biostatistics (Z.C., H.L., P.L., C.A., J.F.L.) and Clinical Neuroscience (T.T.), Karolinska Institutet; Astrid Lindgren Children's Hospital (C.A.), Karolinska University Hospital, Stockholm; Department of Pediatrics (J.F.L.), Örebro University Hospital, Sweden; Division of Epidemiology and Public Health, School of Medicine (J.F.L.), University of Nottingham, UK; and Department of Medicine (J.F.L.), Columbia University, New York, NY.
Torbjörn TomsonFrom the Department of Pediatrics (H.E.K.S.), Linköping University Hospital; Departments of Medical Epidemiology and Biostatistics (Z.C., H.L., P.L., C.A., J.F.L.) and Clinical Neuroscience (T.T.), Karolinska Institutet; Astrid Lindgren Children's Hospital (C.A.), Karolinska University Hospital, Stockholm; Department of Pediatrics (J.F.L.), Örebro University Hospital, Sweden; Division of Epidemiology and Public Health, School of Medicine (J.F.L.), University of Nottingham, UK; and Department of Medicine (J.F.L.), Columbia University, New York, NY.
Jonas F LudvigssonFrom the Department of Pediatrics (H.E.K.S.), Linköping University Hospital; Departments of Medical Epidemiology and Biostatistics (Z.C., H.L., P.L., C.A., J.F.L.) and Clinical Neuroscience (T.T.), Karolinska Institutet; Astrid Lindgren Children's Hospital (C.A.), Karolinska University Hospital, Stockholm; Department of Pediatrics (J.F.L.), Örebro University Hospital, Sweden; Division of Epidemiology and Public Health, School of Medicine (J.F.L.), University of Nottingham, UK; and Department of Medicine (J.F.L.), Columbia University, New York, NY.
Karolinska University Hospital · SEUniversity of Nottingham · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo investigate the association between epilepsy and antiepileptic drugs and serious transport accidents requiring emergency care or resulting in death.

methodsWe identified 29,220 individuals 18 years or older with epilepsy without cerebral palsy or intellectual disability and 267,637 matched controls using Swedish registers. This nationwide cohort was followed from 2006 to 2013 for serious transport accidents. We used Cox regression to analyze the risk of serious transport accidents between individuals with epilepsy and matched controls, and then stratified Cox regression to compare the risk during periods of medication with the risk during nonmedication period within the same individual with epilepsy. We adjusted for civil status, employment, education, living area, psychiatric disorders prior to the start of follow-up, and psychotropic medication.

resultsCompared to matched controls, individuals with epilepsy were at increased risk of serious transport accidents (hazard ratio [HR] 1.37; 95% confidence interval [CI] 1.29-1.46). There were increased risks of pedestrian accidents (HR 2.24, 95% CI 1.69-2.97), bicycle accidents (HR 1.68, 95% CI 1.49-1.89) and car accidents (HR 1.31, 95% CI 1.19-1.44). However, among patients with a diagnosis of epilepsy, use of antiepileptic drugs did not influence the risk of serious transport accidents in population-level comparisons (HR 0.97; 95% CI 0.85-1.11) or within-individual comparisons (HR 0.99; 95% CI 0.69-1.42).

conclusionSerious transportation accidents were more common in individuals with epilepsy, but this risk was independent of use of antiepileptic drugs.

Indexed as

Accidents, TrafficAdolescentAdultAnticonvulsantsCohort StudiesEmergency Medical ServicesEpilepsyFemaleFollow-Up StudiesHumansMaleMental DisordersMiddle AgedPsychotropic DrugsRiskSocioeconomic FactorsAnticonvulsantsPsychotropic Drugs

Identifiers

PMID29490912
PMCPMC5880637
OpenAlexW2766183794

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.