Evidence map›Paper›PMID 29490669›Full record

ArticleAlzheimer's research & therapy2018

Thiamine diphosphate reduction strongly correlates with brain glucose hypometabolism in Alzheimer's disease, whereas amyloid deposition does not.

Shaoming Sang, Xiaoli Pan, Zhichun Chen, Fan Zeng, Shumei Pan, Huimin Liu, Lirong Jin, Guoqiang Fei, Changpeng Wang, Shuhua Ren and 10 more

Open access · goldAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Alzheimer's research & therapy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
5.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 69 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 4 institutions in 1 country.

Shaoming SangDepartment of Neurology, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai, 200032, China.
Xiaoli PanDepartment of Neurology, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai, 200032, China.
Zhichun ChenDepartment of Neurology, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai, 200032, China.
Fan ZengDepartment of Neurology, Daping Hospital, Third Military Medical University, Chongqing, 400042, China.
Shumei PanDepartment of Neurology, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai, 200032, China.
Huimin LiuDepartment of Neurology, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai, 200032, China.
Lirong JinDepartment of Neurology, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai, 200032, China.
Guoqiang FeiDepartment of Neurology, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai, 200032, China.
Changpeng WangDepartment of Neurology, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai, 200032, China.
Shuhua RenPET Center, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Fangyang JiaoPET Center, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Weiqi BaoPET Center, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Weiyan ZhouPET Center, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Yihui GuanPET Center, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Yiqiu ZhangDepartment of Nuclear Medicine, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Hongcheng ShiDepartment of Nuclear Medicine, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Yanjiang WangDepartment of Neurology, Daping Hospital, Third Military Medical University, Chongqing, 400042, China.
Xiang YuInstitute of Neuroscience, State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, 200031, China.
Yun WangDepartment of Neurology, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai, 200032, China. wangyun@fudan.edu.cn.
Chunjiu ZhongDepartment of Neurology, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai, 200032, China. zhongcj@163.com.ORCID 0000-0001-7870-3441
Fudan University · CNArmy Medical University · CNSun Yat-sen University · CNChinese Academy of Sciences · CN

Funding

the National Key Research and Development Program Foundation of China 2016YFC1306403the National Natural Science Foundation of China 91332201, 81071019, 81500907, 31471027the Natural Science Foundation of Shanghai 13JC1401501
6 · The paper itself

Abstract

backgroundThe underlying mechanism of brain glucose hypometabolism, an invariant neurodegenerative feature that tightly correlates with cognitive impairment and disease progression of Alzheimer's disease (AD), remains elusive.

methodsPositron emission tomography with 2-[

resultsFDG SUVRs in frontal, temporal, and parietal cortices of patients with AD were closely correlated with the levels of blood thiamine diphosphate (TDP) and cognitive abilities, but not with brain Aβ deposition. Mice on a thiamine-deprived diet manifested a significant decline of FDG SUVRs in multiple brain regions as compared with those in control mice, with magnitudes highly correlating with both brain and blood TDP levels. There were no significant differences in the changes of FDG SUVRs in observed brain regions between amyloid precursor protein/presenilin-1 and wild-type mice following thiamine deficiency.

conclusionsWe demonstrate, for the first time to our knowledge, in vivo that TDP reduction strongly correlates with brain glucose hypometabolism, whereas amyloid deposition does not. Our study provides new insight into the pathogenesis and therapeutic strategy for AD.

Indexed as

AgedAged, 80 and overAge FactorsAlzheimer DiseaseAmyloid beta-PeptidesAmyloid beta-Protein PrecursorAniline CompoundsAnimalsBrainDisease Models, AnimalFemaleFluorodeoxyglucose F18GlucoseHumansMaleMice2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazoleAmyloid beta-PeptidesAmyloid beta-Protein PrecursorAniline CompoundsFluorodeoxyglucose F18GlucosePresenilin-1ThiamineThiamine PyrophosphateThiazolesAlzheimer’s diseaseAmyloid-βBrain glucose metabolismPosition emission tomographyThiamine diphosphate

Identifiers

PMID29490669
PMCPMC5831864
OpenAlexW2796357093

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.