ArticleBMC musculoskeletal disorders2018
Clinical and imaging characteristics in patients undergoing surgery for lumbar epidural lipomatosis.
Article in BMC musculoskeletal disorders, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Acellular, bioresorbable, ultra-purified alginate gel implantation for intervertebral disc herniation: Phase 1/2, open-label, non-randomized clinical trials.Nature communications · 2025Trial
- Resolution of severe lumbar spinal epidural lipomatosis following tirzepatide-induced weight loss: illustrative case.Journal of neurosurgery. Case lessons · 2026Article
- Insights into the Pathophysiology of Scheuermann's Kyphosis: From Structural Deformities to Genetic Predisposition and Underlying Signalling Pathways.Biomolecules · 2025Review
- Case Report: Electrophysiological characteristics of the pelvic floor in spinal epidural lipomatosis.Frontiers in rehabilitation sciences · 2025Article
- Neurologic pathologies of the vertebral spine.Skeletal radiology · 2024Review
- Outcome of posterior decompression for spinal epidural lipomatosis.Acta neurochirurgica · 2023Article
- Loss of CSF-contacting neuron sensory function is associated with a hyper-kyphosis of the spine reminiscent of Scheuermann's disease.Scientific reports · 2023Article
- Article
- Is there an association between lumbosacral epidural lipomatosis and lumbosacral epidural steroid injections? A comprehensive narrative literature review.North American Spine Society journal · 2022Article
- Spinal Epidural Lipoma on the Ventral Dura Side and Intervertebral Foramen Causing Lumbar Radiculopathy.Case reports in orthopedics · 2022Article
- Bilateral Lower Extremity Weakness: Spinal Epidural Lipomatosis or more?Orthopedic reviews · 2022Review
- Surgical management of thoracic myelopathy from long-segment epidural lipomatosis with skip hemilaminotomies: illustrative case.Journal of neurosurgery. Case lessons · 2021Article
- Exploratory clinical trial on the safety and capability of dMD-001 in lumbar disc herniation: Study protocol for a first-in-human pilot study.Contemporary clinical trials communications · 2021Article
- Epidural lipomatosis in elderly patient: A rare cause of cauda equina compression.Surgical neurology international · 2021Article
- Spinal Epidural Lipomatosis: A Comprehensive Review.Orthopedic reviews · 2021Review
- Osteopathic Considerations for Peripheral Neuropathy Due to Concomitant Diffuse Idiopathic Skeletal Hyperostosis Syndrome and Lumbar Epidural Lipomatosis: Case Report.Interactive journal of medical research · 2019Article
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10 authors.
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Abstract
backgroundLumbar epidural lipomatosis (LEL) is characterized by abnormal accumulation of unencapsulated adipose tissue in the spinal epidural space. Such accumulation compresses the dural sac and nerve roots, and results in various neurological findings. However, the pathophysiology of LEL remains unclear. This study examined the associations between imaging and clinical findings in detail, and investigated the mechanisms underlying symptom onset by measuring intraoperative epidural pressures in LEL.
methodsSixteen patients (all men; mean age, 68.8 years) were enrolled between 2011 and 2015. Mean body mass index was 26.5 kg/m
resultsSubjective symptoms improved within 1 week after surgery. Mean Japanese Orthopaedic Association (JOA) score was 15.2 ± 2.8 before surgery, improving to 25.4 ± 2.5 at 1 year after surgery. On magnetic resonance imaging, all lipomatosis lesions included the L4-5 level. On preoperative computed tomography, saucerization of the laminae was not observed in radiculopathy cases, whereas saucerization of the posterior vertebral body was observed in all radiculopathy or mixed CES cases. Intraoperative epidural pressures were significantly higher than preoperative subarachnoid pressures. The results suggest that high epidural pressure resulting from the proliferation of adipose tissue leads to saucerization of the lumbar spine and subsequent symptoms.
conclusionsClinical courses were satisfactory after laminectomy. In LEL, epidural pressure increases and symptoms develop through the abnormal proliferation of adipose tissue. Higher epidural pressures induce saucerization of the laminae and/or posterior vertebral body. Furthermore, the direction of proliferative adipose tissue (i.e., site of saucerization) might be related to the types of neurological symptoms.
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